Association between common alleles of the low-density lipoprotein receptor gene region and interindividual variation in plasma lipid and apolipoprotein levels in a population-based sample from Rochester, Minnesota
dc.contributor.author | Sing, Charles F. | en_US |
dc.contributor.author | Haviland, Martha B. | en_US |
dc.contributor.author | Ferrell, Robert E. | en_US |
dc.date.accessioned | 2006-09-08T20:09:17Z | |
dc.date.available | 2006-09-08T20:09:17Z | |
dc.date.issued | 1996-12 | en_US |
dc.identifier.citation | Haviland, M. B.; Ferrell, R. E.; Sing, C. F.; (1996). "Association between common alleles of the low-density lipoprotein receptor gene region and interindividual variation in plasma lipid and apolipoprotein levels in a population-based sample from Rochester, Minnesota." Human Genetics 99(1): 108-114. <http://hdl.handle.net/2027.42/42270> | en_US |
dc.identifier.issn | 0340-6717 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42270 | |
dc.description.abstract | This paper presents an analysis of the relationship between variation in the low-density lipoprotein receptor (LDLR) gene region and interindividual variation in plasma lipid and apolipoprotein levels in a sample representative of the adult population of Rochester, Minn. (217 females and 187 males aged 26 to 63). This relationship was analyzed by estimating the average excesses of alleles of the LDLR gene defined using RFLP markers both singly and simultaneously. We also used a cladistic approach to illustrate the consequences of incorporating evolutionary information into the analysis of genotype-phenotype relationships. Although results from both approaches supported the inference that common variation in the LDLR gene region associates with small effects on plasma lipid and apolipoprotein levels, only the cladistic approach provides direction for further work aimed at identifying the functional DNA sequence variations responsible for the observed associations. | en_US |
dc.format.extent | 49056 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | Legacy | en_US |
dc.title | Association between common alleles of the low-density lipoprotein receptor gene region and interindividual variation in plasma lipid and apolipoprotein levels in a population-based sample from Rochester, Minnesota | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, M4708 Medical Science Bldg. II, University of Michigan Medical School, Ann Arbor, MI 48109-0618, USA, US | en_US |
dc.contributor.affiliationum | Department of Human Genetics, M4708 Medical Science Bldg. II, University of Michigan Medical School, Ann Arbor, MI 48109-0618, USA, US | en_US |
dc.contributor.affiliationother | Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15 261, USA, US | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42270/1/439-99-1-108_60990108.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s004390050322 | en_US |
dc.identifier.source | Human Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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