Quantitative morphometry of renal biopsies prior to cyclosporine in nephrotic syndrome
dc.contributor.author | Johnson, Kent J. | en_US |
dc.contributor.author | Bajwa, Ravinder S. | en_US |
dc.contributor.author | Bunchman, Timothy E. | en_US |
dc.contributor.author | Smoyer, William E. | en_US |
dc.contributor.author | Gregory, Melissa J. | en_US |
dc.date.accessioned | 2006-09-08T20:11:19Z | |
dc.date.available | 2006-09-08T20:11:19Z | |
dc.date.issued | 1998-11 | en_US |
dc.identifier.citation | Smoyer, William E.; Gregory, Melissa J.; Bajwa, Ravinder S.; Johnson, Kent J.; Bunchman, Timothy E.; (1998). "Quantitative morphometry of renal biopsies prior to cyclosporine in nephrotic syndrome." Pediatric Nephrology 12(9): 737-743. <http://hdl.handle.net/2027.42/42297> | en_US |
dc.identifier.issn | 0931-041X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42297 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9874317&dopt=citation | en_US |
dc.description.abstract | Use of cyclosporine (CsA) in the management of children with steroid-resistant (SRNS) and steroid-dependent (SDNS) nephrotic syndrome has become increasingly popular in recent years. Although most children receive a renal biopsy prior to initiation of CsA, the relationship between initial renal histology and the subsequent clinical response to CsA is not known. We analyzed the correlation between pre-CsA segmental and global glomerular scarring and interstitial fibrosis and the subsequent response to CsA in 23 children (5.6±1.0 years, Mean±SEM) with SDNS ( n =8) and SRNS ( n =15) treated with CsA for 24.2±3.8 months and followed for 28.0±4.1 months. Complete remission was obtained in 78% of patients within 67.6±16 days, while 18% had a partial response and 4% no response. Quantitative histological analysis revealed a trend toward partial rather than complete response with increasing segmental glomerular ( P =0.13), global glomerular ( P =0.05), and interstitial ( P =0.08) scarring, and among patients with minimal change nephrotic syndrome versus IgM nephropathy versus focal segmental glomerulosclerosis. Among complete responders, linear regression analyses revealed no correlation between time to response and pre-CsA glomerular or interstitial scarring. We conclude that increased glomerular or interstitial scarring on a pre-CsA renal biopsy tends to correlate with a partial, rather than complete, response to CsA in childhood nephrotic syndrome. | en_US |
dc.format.extent | 164999 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; IPNA - International Pediatric Nephrology Association New York, USA | en_US |
dc.subject.other | Focal Segmental Glomerulosclerosis | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Glomerulosclerosis | en_US |
dc.subject.other | IgM Nephropathy | en_US |
dc.subject.other | Key Words: Interstitial Fibrosis | en_US |
dc.title | Quantitative morphometry of renal biopsies prior to cyclosporine in nephrotic syndrome | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationother | Department of Pediatrics, University of Rochester, New York, USA, US | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 9874317 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42297/1/467-12-9-737_80120737.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s004670050536 | en_US |
dc.identifier.source | Pediatric Nephrology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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