Empirical validation of a two-state kinetic model for the B-Z transition of double-stranded poly[d(G-m 5 C)]
dc.contributor.author | Fuertes, M. A. | en_US |
dc.contributor.author | González, Víctor Manuel | en_US |
dc.contributor.author | Pérez, José Manuel | en_US |
dc.contributor.author | Alonso, Carlos | en_US |
dc.date.accessioned | 2006-09-08T20:13:06Z | |
dc.date.available | 2006-09-08T20:13:06Z | |
dc.date.issued | 1999-12 | en_US |
dc.identifier.citation | Fuertes, M. A.; Pérez, José Manuel; González, Víctor Manuel; Alonso, Carlos; (1999). "Empirical validation of a two-state kinetic model for the B-Z transition of double-stranded poly[d(G-m 5 C)]." Journal of Biological Inorganic Chemistry 4(6): 759-765. <http://hdl.handle.net/2027.42/42325> | en_US |
dc.identifier.issn | 0949-8257 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42325 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10631607&dopt=citation | en_US |
dc.description.abstract | C)] in terms of the salt concentration, the absolute temperature, and the cooperativity index. The validity of the formula was tested using circular dichroism spectroscopy after variation of the type of salt (NaCl, MgCl 2 ), the salt concentration, and the temperature of the polynucleotide solution. A consequence of the proposed function is that in conditions of high salt there is a predictable salt threshold which determines the particular molecular mechanism of the B-Z transition. The paper also describes the way in which this threshold level is temperature dependent. A detailed comparison of our data with the experimental data found by other authors is given. The function agrees quantitatively with the experiments and explains the contrasting results found in the literature about the influence in the B-Z transition of both the temperature and the polymer size. | en_US |
dc.format.extent | 159087 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Society of Biological Inorganic Chemistry | en_US |
dc.subject.other | Salt Dependence | en_US |
dc.subject.other | Circular Dichroism Spectroscopy | en_US |
dc.subject.other | Left-handed DNA | en_US |
dc.subject.other | Temperature Dependence | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Synthetic Polynucleotide | en_US |
dc.title | Empirical validation of a two-state kinetic model for the B-Z transition of double-stranded poly[d(G-m 5 C)] | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor MI 48109-0668, USA, US | en_US |
dc.contributor.affiliationother | Departamento de Química Inorgánica, Facultad de Ciencias Universidad Autónoma de Madrid, Cantoblanco E-28049 Madrid, Spain, ES | en_US |
dc.contributor.affiliationother | Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM) Facultad de Ciencias, Universidad Autónoma de Madrid Cantoblanco, E-28049 Madrid, Spain e-mail: mafuertes@trasto.cbm.uam.es, Tel.: +34-91-3978463, Fax: +34-91-3974799, ES | en_US |
dc.contributor.affiliationother | Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM) Facultad de Ciencias, Universidad Autónoma de Madrid Cantoblanco, E-28049 Madrid, Spain e-mail: mafuertes@trasto.cbm.uam.es, Tel.: +34-91-3978463, Fax: +34-91-3974799, ES | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 10631607 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42325/1/775-4-6-759_90040759.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s007750050348 | en_US |
dc.identifier.source | Journal of Biological Inorganic Chemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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