Absence of Protein Polymorphism in the Ras Genes of Drosophila melanogaster
dc.contributor.author | Gasperini, Robert | en_US |
dc.contributor.author | Gibson, Greg | en_US |
dc.date.accessioned | 2006-09-08T20:15:59Z | |
dc.date.available | 2006-09-08T20:15:59Z | |
dc.date.issued | 1999-11 | en_US |
dc.identifier.citation | Gasperini, Robert; Gibson, Greg; (1999). "Absence of Protein Polymorphism in the Ras Genes of Drosophila melanogaster ." Journal of Molecular Evolution 49(5): 583-590. <http://hdl.handle.net/2027.42/42369> | en_US |
dc.identifier.issn | 0022-2844 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42369 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10552039&dopt=citation | en_US |
dc.description.abstract | Sequence analysis of 27 alleles of each of the three Ras -related genes in Drosophila melanogaster indicates that they all have low levels of polymorphism but may experience slightly different evolutionary pressures. No amino acid replacement substitutions were indicated in any of the sequences, or in the sibling species D. simulans and D. mauritiana. The Dras1 gene, which is the major ras homologue in Drosophila, has less within-species variation in D. melanogaster relative to the amount of divergence from the sibling species than does Dras2, although the contrast was not significant by the HKA test. Dras2 appears to be maintaining two classes of haplotype in D. melanogaster, one of which is closer to the alleles observed in the sibling species, suggesting that this is not likely to be a pseudogene despite the absence of a mutant phenotype. Although differences in level of expression may affect the function of the genes, it is concluded that genetic variation in the Ras signal transduction pathways cannot be attributed to catalytic variation in the Ras proteins. | en_US |
dc.format.extent | 541703 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag New York Inc. | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Key Words:Drosophila Melanogaster— Ras — Rap — HKA Test — Polymorphism — Oncogene | en_US |
dc.title | Absence of Protein Polymorphism in the Ras Genes of Drosophila melanogaster | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan, Ann Arbor, MI 48109-1048, USA, US, | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan, Ann Arbor, MI 48109-1048, USA, US, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 10552039 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42369/1/239-49-5-583_49n5p583.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/PL00006579 | en_US |
dc.identifier.source | Journal of Molecular Evolution | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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