The Influence of a Restrictive Atrial Septal Defect on Pulmonary Vascular Morphology in Patients with Hypoplastic Left Heart Syndrome
dc.contributor.author | Heidelberger, Kathleen P. | en_US |
dc.contributor.author | Ludomirsky, Achi | en_US |
dc.contributor.author | Ensing, Gregory J. | en_US |
dc.contributor.author | Graziano, Joseph N. | en_US |
dc.contributor.author | Gomez, C. A. | en_US |
dc.date.accessioned | 2006-09-08T20:17:04Z | |
dc.date.available | 2006-09-08T20:17:04Z | |
dc.date.issued | 2002-03 | en_US |
dc.identifier.citation | Graziano, J.N.; Heidelberger, K.P.; Ensing, G.J.; Gomez, C.A.; Ludomirsky, A.; (2002). "The Influence of a Restrictive Atrial Septal Defect on Pulmonary Vascular Morphology in Patients with Hypoplastic Left Heart Syndrome." Pediatric Cardiology 23(2): 146-151. <http://hdl.handle.net/2027.42/42386> | en_US |
dc.identifier.issn | 0172-0643 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42386 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11889524&dopt=citation | en_US |
dc.description.abstract | Hypoplastic left heart syndrome (HLHS) with a restrictive atrial septal defect (ASD) is a form of congenital heart disease with considerable morbidity and mortality. This morphologic analysis assesses the pulmonary vasculature in this patient population. Pulmonary arteries, the persistence of high-resistance fetal arterioles, pulmonary veins, and lymphatics from multiple lung sections from each of five patients with HLHS and a restrictive ASD were compared to those of five patients with HLHS and nonrestrictive ASD. Lung sections from each patient were qualitatively graded in severity of pathology from 0 to 3 for each of the structures described previously, with the pathologist blinded to the status of the ASD. Patients with a restrictive ASD exhibited more significant pulmonary venous thickening and lymphatic dilatation (p = 0.02), with a tendency toward persistence of high-resistance fetal vessels (p = 0.2), compared to patients with a nonrestrictive ASD. These findings imply that patients with HLHS and a restrictive ASD possess pulmonary vascular abnormalities that place them at higher risk for the current surgical interventions available compared to patients with a nonrestrictive ASD. | en_US |
dc.format.extent | 161289 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag New York Inc. | en_US |
dc.subject.other | Legacy | en_US |
dc.title | The Influence of a Restrictive Atrial Septal Defect on Pulmonary Vascular Morphology in Patients with Hypoplastic Left Heart Syndrome | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Pediatric Cardiology, University of Michigan, Ann Arbor, MI 48109, USA, US, | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Pediatric Cardiology, University of Michigan, Ann Arbor, MI 48109, USA, US, | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Pediatric Cardiology, University of Michigan, Ann Arbor, MI 48109, USA, US, | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA, US, | en_US |
dc.contributor.affiliationum | Department of Pediatrics, Division of Pediatric Cardiology, University of Michigan, Ann Arbor, MI 48109, USA, US, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 11889524 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42386/1/246-23-2-146_20230146.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00246-001-0038-7 | en_US |
dc.identifier.source | Pediatric Cardiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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