Arsenic resistance in the archaeon "Ferroplasma acidarmanus" : new insights into the structure and evolution of the ars genes
dc.contributor.author | Banfield, Jillian F. | en_US |
dc.contributor.author | Gihring, Thomas M. | en_US |
dc.contributor.author | Peters, Stephen C. | en_US |
dc.contributor.author | Bond, Philip L. | en_US |
dc.date.accessioned | 2006-09-08T20:20:47Z | |
dc.date.available | 2006-09-08T20:20:47Z | |
dc.date.issued | 2003-04 | en_US |
dc.identifier.citation | Gihring, Thomas M.; Bond, Philip L.; Peters, Stephen C.; Banfield, Jillian F.; (2003). "Arsenic resistance in the archaeon "Ferroplasma acidarmanus" : new insights into the structure and evolution of the ars genes." Extremophiles 7(2): 123-130. <http://hdl.handle.net/2027.42/42444> | en_US |
dc.identifier.issn | 1431-0651 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42444 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12664264&dopt=citation | en_US |
dc.description.abstract | Arsenic resistance in the acidophilic iron-oxidizing archaeon " Ferroplasma acidarmanus " was investigated. F. acidarmanus is native to arsenic-rich environments, and culturing experiments confirm a high level of resistance to both arsenite and arsenate. Analyses of the complete genome revealed protein-encoding regions related to known arsenic-resistance genes. Genes encoding for ArsR (arsenite-sensitive regulator) and ArsB (arsenite-efflux pump) homologues were found located on a single operon. A gene encoding for an ArsA relative (anion-translocating ATPase) located apart from the arsRB operon was also identified. Arsenate-resistance genes encoding for proteins homologous to the arsenate reductase ArsC and the phosphate-specific transporter Pst were not found, indicating that additional unknown arsenic-resistance genes exist for arsenate tolerance. Phylogenetic analyses of ArsA-related proteins suggest separate evolutionary lines for these proteins and offer new insights into the formation of the arsA gene. The ArsB-homologous protein of F. acidarmanus had a high degree of similarity to known ArsB proteins. An evolutionary analysis of ArsB homologues across a number of species indicated a clear relationship in close agreement with 16S rRNA evolutionary lines. These results support a hypothesis of arsenic resistance developing early in the evolution of life. | en_US |
dc.format.extent | 951011 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Arsenic Resistance Ars Ferroplasma Acidarmanus Acidophile Evolution Phylogeny Genomics | en_US |
dc.subject.other | Legacy | en_US |
dc.title | Arsenic resistance in the archaeon "Ferroplasma acidarmanus" : new insights into the structure and evolution of the ars genes | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Geological Sciences, The University of Michigan, Ann Arbor, Michigan, USA, | en_US |
dc.contributor.affiliationother | School of Biological Sciences, University of East Anglia, Norwich, UK, | en_US |
dc.contributor.affiliationother | Department of Geology and Geophysics, The University of Wisconsin Madison, Madison, Wisconsin, USA, | en_US |
dc.contributor.affiliationother | Department of Geology and Geophysics, The University of Wisconsin Madison, Madison, Wisconsin, USA, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 12664264 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42444/1/s00792-002-0303-6.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00792-002-0303-6 | en_US |
dc.identifier.source | Extremophiles | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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