Optochemical Nanosensors and Subcellular Applications in Living Cells
dc.contributor.author | Kopelman, Raoul | en_US |
dc.contributor.author | Philbert, Martin A. | en_US |
dc.contributor.author | Clark, Heather A. | en_US |
dc.contributor.author | Hoyer, Marion E. | en_US |
dc.contributor.author | Parus, Stephan J. | en_US |
dc.date.accessioned | 2006-09-08T20:21:03Z | |
dc.date.available | 2006-09-08T20:21:03Z | |
dc.date.issued | 1999-06 | en_US |
dc.identifier.citation | Clark, Heather A.; Hoyer, Marion; Parus, Steve; Philbert, Martin A.; Kopelman, Raoul; (1999). "Optochemical Nanosensors and Subcellular Applications in Living Cells." Mikrochimica Acta 131 (1-2): 121-128. <http://hdl.handle.net/2027.42/42448> | en_US |
dc.identifier.issn | 0026-3672 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42448 | |
dc.description.abstract | What may be the smallest anthropogenic devices to date, spherical sensors (wireless and fiberless) with radii as small as 10 nm have been produced. This class of optochemical PEBBLE (Probe Encapsulated By Biologically Localized Embedding) sensors covers a wide range of analytes (pH, calcium, oxygen and potassium included here) with excellent spatial, temporal and chemical resolution. Examples of such sensors for the monitoring of intracellular analytes are given. Methods, such as pico-injection, liposomal delivery and gene gun bombardment, are used to inject PEBBLE sensors into single cells. These PEBBLEs have caused minimal perturbation when delivered and operated inside single mammalian cells, such as human neuroblastoma, mouse oocytes or rat alveolar macrophage. | en_US |
dc.format.extent | 455291 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Wien | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Key Words: Optodes; Nanosensor; Cellular Probes; Sensors. | en_US |
dc.title | Optochemical Nanosensors and Subcellular Applications in Living Cells | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA, US | en_US |
dc.contributor.affiliationum | Department of Environmental and Industrial Health, University of Michigan, MI, USA, US | en_US |
dc.contributor.affiliationum | Department of Environmental and Industrial Health, University of Michigan, MI, USA, US | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA, US | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA, US | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42448/1/604-131-1-2-121_91310121.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s006040050017 | en_US |
dc.identifier.source | Mikrochimica Acta | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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