The cell receptor level is reduced during persistent infection with influenza C virus
dc.contributor.author | Zimmer, G. | en_US |
dc.contributor.author | Maassab, Hunein F. | en_US |
dc.contributor.author | Marschall, M. | en_US |
dc.contributor.author | Herrler, G. | en_US |
dc.contributor.author | Meier-Ewert, H. | en_US |
dc.date.accessioned | 2006-09-08T20:21:45Z | |
dc.date.available | 2006-09-08T20:21:45Z | |
dc.date.issued | 1997-06 | en_US |
dc.identifier.citation | Marschall, M.; Meier-Ewert, H.; Herrler, G.; Zimmer, G.; Maassab, H. F.; (1997). "The cell receptor level is reduced during persistent infection with influenza C virus." Archives of Virology 142(6): 1155-1164. <http://hdl.handle.net/2027.42/42459> | en_US |
dc.identifier.issn | 0304-8608 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42459 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9229005&dopt=citation | en_US |
dc.description.abstract | Persistent influenza C virus infection of MDCK cells perpetuates the viral genome in a cell-associated form. Typically, virus production remains at a low level over extended periods, in the absence of lytic effects of replication. In this study, we demonstrate that persistently infected cells are very restricted in permissiveness for superinfection. By reconstitution experiments, using bovine brain gangliosides as artificial receptors, the degree of super-infection was markedly increased. Analysis of cellular receptor expression revealed reduced concentrations of sialoglycoproteins in general and a limited presentation of the major receptor gp40. Cocultures of persistently infected and uninfected cells (the latter carrying normal receptor levels) initiated a transient rise in virus titers. This kind of induction of virus synthesis appeared to be mainly receptor-linked, since a receptor-deprived subline, MDCK II, did not give rise to a similar effect. Susceptibility of MDCK II cocultures could be partly restored by ganglioside treatment. In accordance to related virus systems, these findings on influenza C virus suggest a role of cell receptor concentrations in the regulation of long-term persistence. | en_US |
dc.format.extent | 381728 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; 1997 Springer-Verlag/ | en_US |
dc.subject.other | Legacy | en_US |
dc.title | The cell receptor level is reduced during persistent infection with influenza C virus | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, University of Michigan, Ann Arbor,Michigan, U.S.A., US | en_US |
dc.contributor.affiliationother | Institut für Virologie, Philipps-Universität Marburg, Marburg, Germany, DE | en_US |
dc.contributor.affiliationother | Institut für Virologie, Philipps-Universität Marburg, Marburg, Germany, DE | en_US |
dc.contributor.affiliationother | Abteilung für Virologie, Institut für Medizinische Mikrobiologie, Immunologieund Hygiene, Technische Universität München, München, Germany, DE | en_US |
dc.contributor.affiliationother | Abteilung für Virologie, Institut für Medizinische Mikrobiologie, Immunologieund Hygiene, Technische Universität München, München, Germany, DE | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 9229005 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42459/1/705-142-6-1155_71421155.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s007050050149 | en_US |
dc.identifier.source | Archives of Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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