Effect of lead acetate on Sertoli cell lactate production and protein synthesis in vitro
dc.contributor.author | Batarseh, Layla I. | en_US |
dc.contributor.author | Welsh, Michael J. | en_US |
dc.contributor.author | Brabec, Michael J. | en_US |
dc.date.accessioned | 2006-09-08T20:27:39Z | |
dc.date.available | 2006-09-08T20:27:39Z | |
dc.date.issued | 1986-06 | en_US |
dc.identifier.citation | Batarseh, Layla I.; Welsh, Michael J.; Brabec, Michael J.; (1986). "Effect of lead acetate on Sertoli cell lactate production and protein synthesis in vitro ." Cell Biology and Toxicology 2(2): 283-292. <http://hdl.handle.net/2027.42/42549> | en_US |
dc.identifier.issn | 0742-2091 | en_US |
dc.identifier.issn | 1573-6822 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42549 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3267452&dopt=citation | en_US |
dc.description.abstract | The effects of lead acetate on protein synthesis and lactate production by cultures of rat Sertoli cells in vitro were studied. Sertoli cell cultures prepared from 20 day old Sprague-Dawley rats were exposed to 0.01, 0.05 and 0.10 mM lead acetate. Lactate production was significantly elevated by all concentrations of lead after 3, 6, 9 and 12 hours of exposure. Protein biosynthesis as measured by [ 3 H]-leucine incorporation was significantly depressed by 0.05 and 0.10 mM lead acetate after 2 hours of exposure. These results support the hypothesis that lead acetate may inhibit spermatogenesis by a disturbance of the metabolic activities of the Sertoli cells. | en_US |
dc.format.extent | 696100 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Princeton Sceintific Publishing Co., Inc. ; Springer Science+Business Media | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Veterinary Medicine | en_US |
dc.subject.other | Animal Anatomy / Morphology / Histology | en_US |
dc.subject.other | Lactate | en_US |
dc.subject.other | Lead | en_US |
dc.subject.other | Sertoli Cell | en_US |
dc.subject.other | Spermatogenesis | en_US |
dc.subject.other | Rat | en_US |
dc.title | Effect of lead acetate on Sertoli cell lactate production and protein synthesis in vitro | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Environmental and Industrial Health School of Public Health, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Anatomy and Cell Biology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Environmental and Industrial Health School of Public Health, The University of Michigan, Ann Arbor, Michigan; Department of Chemistry, Eastern Michigan University, 48197, Ypsilanti, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3267452 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42549/1/10565_2004_Article_BF00122696.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00122696 | en_US |
dc.identifier.source | Cell Biology and Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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