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Effect of lead acetate on Sertoli cell lactate production and protein synthesis in vitro

dc.contributor.authorBatarseh, Layla I.en_US
dc.contributor.authorWelsh, Michael J.en_US
dc.contributor.authorBrabec, Michael J.en_US
dc.date.accessioned2006-09-08T20:27:39Z
dc.date.available2006-09-08T20:27:39Z
dc.date.issued1986-06en_US
dc.identifier.citationBatarseh, Layla I.; Welsh, Michael J.; Brabec, Michael J.; (1986). "Effect of lead acetate on Sertoli cell lactate production and protein synthesis in vitro ." Cell Biology and Toxicology 2(2): 283-292. <http://hdl.handle.net/2027.42/42549>en_US
dc.identifier.issn0742-2091en_US
dc.identifier.issn1573-6822en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/42549
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3267452&dopt=citationen_US
dc.description.abstractThe effects of lead acetate on protein synthesis and lactate production by cultures of rat Sertoli cells in vitro were studied. Sertoli cell cultures prepared from 20 day old Sprague-Dawley rats were exposed to 0.01, 0.05 and 0.10 mM lead acetate. Lactate production was significantly elevated by all concentrations of lead after 3, 6, 9 and 12 hours of exposure. Protein biosynthesis as measured by [ 3 H]-leucine incorporation was significantly depressed by 0.05 and 0.10 mM lead acetate after 2 hours of exposure. These results support the hypothesis that lead acetate may inhibit spermatogenesis by a disturbance of the metabolic activities of the Sertoli cells.en_US
dc.format.extent696100 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers; Princeton Sceintific Publishing Co., Inc. ; Springer Science+Business Mediaen_US
dc.subject.otherLife Sciencesen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherVeterinary Medicineen_US
dc.subject.otherAnimal Anatomy / Morphology / Histologyen_US
dc.subject.otherLactateen_US
dc.subject.otherLeaden_US
dc.subject.otherSertoli Cellen_US
dc.subject.otherSpermatogenesisen_US
dc.subject.otherRaten_US
dc.titleEffect of lead acetate on Sertoli cell lactate production and protein synthesis in vitroen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Environmental and Industrial Health School of Public Health, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Anatomy and Cell Biology, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Environmental and Industrial Health School of Public Health, The University of Michigan, Ann Arbor, Michigan; Department of Chemistry, Eastern Michigan University, 48197, Ypsilanti, Michiganen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid3267452en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/42549/1/10565_2004_Article_BF00122696.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00122696en_US
dc.identifier.sourceCell Biology and Toxicologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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