PCNA levels in neuroblastoma are increased in tumors with an amplified N- myc gene and in metastatic stage tumors
dc.contributor.author | Keim, David R. | en_US |
dc.contributor.author | Hailat, Nabil | en_US |
dc.contributor.author | Kuick, Rork | en_US |
dc.contributor.author | Reynolds, C. Patrick | en_US |
dc.contributor.author | Brodeur, Garrett M. | en_US |
dc.contributor.author | Seeger, Robert C. | en_US |
dc.contributor.author | Hanash, Samir M. | en_US |
dc.date.accessioned | 2006-09-08T20:29:44Z | |
dc.date.available | 2006-09-08T20:29:44Z | |
dc.date.issued | 1993-01 | en_US |
dc.identifier.citation | Keim, David R.; Hailat, Nabil; Kuick, Rork; Reynolds, C. Patrick; Brodeur, Garrett M.; Seeger, Robert C.; Hanash, Samir M.; (1993). "PCNA levels in neuroblastoma are increased in tumors with an amplified N- myc gene and in metastatic stage tumors." Clinical & Experimental Metastasis 11(1): 83-90. <http://hdl.handle.net/2027.42/42581> | en_US |
dc.identifier.issn | 0262-0898 | en_US |
dc.identifier.issn | 1573-7276 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42581 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8093685&dopt=citation | en_US |
dc.description.abstract | N- myc oncogene amplification in neuroblastoma has been found to be significantly associated with advanced stage disease and tumor progression. However, there is a lack of data on tumors, regarding the relationship between N- myc gene amplification and proliferation activity. Proliferating cell nuclear antigen (PCNA) is a proliferation-induced 36 kD nuclear protein that is the auxiliary component of DNA polymerase δ. PCNA levels in tissues have been found to correlate with proliferative activity. We have examined PCNA levels in neuroblastomas in relation to N- myc gene amplification and tumor stage. Statistically, significantly higher levels of PCNA were observed in tumors with an amplified N- myc gene relative to tumors with a single gene copy. The highest levels of PCNA were observed in advanced stage tumors with an amplified N- myc gene. Treatment of neuroblastoma cells in culture with retinoic acid, which induces differentiation, resulted in a substantial decrease in PCNA. Our results suggest that PCNA levels may reflect differences in proliferative activity between neuroblastomas, related to stage of the disease and to N- myc gene copy number.[/p ] | en_US |
dc.format.extent | 675047 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Rapid Communications of Oxford Ltd. ; Springer Science+Business Media | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Hematology | en_US |
dc.subject.other | Surgical Oncology | en_US |
dc.subject.other | Pathology | en_US |
dc.subject.other | Metastasis | en_US |
dc.subject.other | Neuroblastoma | en_US |
dc.subject.other | Oncogene | en_US |
dc.title | PCNA levels in neuroblastoma are increased in tumors with an amplified N- myc gene and in metastatic stage tumors | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatric Hematology, University of Michigan Medical School, R4451 Kresge I, Box 0510, 48109-0510, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Pediatric Hematology, University of Michigan Medical School, R4451 Kresge I, Box 0510, 48109-0510, Ann Arbor, MI; Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Israel | en_US |
dc.contributor.affiliationum | Department of Pediatric Hematology, University of Michigan Medical School, R4451 Kresge I, Box 0510, 48109-0510, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Pediatric Hematology, University of Michigan Medical School, R4451 Kresge I, Box 0510, 48109-0510, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Childrens Hospital of Los Angeles, Department of Pediatrics, Division of Pediatric Hematology/Oncology and Children's Cancer Study Group, University of Southern California School of Medicine, 90027, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Pediatrics and Pediatric Oncology Group, Washington University School of Medicine, 63310, St Louis, MO, USA | en_US |
dc.contributor.affiliationother | Childrens Hospital of Los Angeles, Department of Pediatrics, Division of Pediatric Hematology/Oncology and Children's Cancer Study Group, University of Southern California School of Medicine, 90027, Los Angeles, CA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8093685 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42581/1/10585_2004_Article_BF00880069.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00880069 | en_US |
dc.identifier.source | Clinical & Experimental Metastasis | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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