Application of cladistics to the analysis of genotype-phenotype relationships
dc.contributor.author | Sing, Charles F. | en_US |
dc.contributor.author | Haviland, Martha B. | en_US |
dc.contributor.author | Zerba, Kim E. | en_US |
dc.contributor.author | Templeton, Alan R. | en_US |
dc.date.accessioned | 2006-09-08T20:35:14Z | |
dc.date.available | 2006-09-08T20:35:14Z | |
dc.date.issued | 1992-05 | en_US |
dc.identifier.citation | Sing, C. F.; Haviland, M. B.; Zerba, K. E.; Templeton, A. R.; (1992). "Application of cladistics to the analysis of genotype-phenotype relationships." European Journal of Epidemiology 8(1): 3-9. <http://hdl.handle.net/2027.42/42664> | en_US |
dc.identifier.issn | 0392-2990 | en_US |
dc.identifier.issn | 1573-7284 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42664 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1354623&dopt=citation | en_US |
dc.description.abstract | We seek to understand the relative contribution of allelic variations of a particular gene to the determination of an individual's risk of atherosclerosis or hypertension. Work in progress is focusing on the identification and characterization of mutations in candidate genes that are known to be involved in determining the phenotypic expression of intermediate biochemical and physiological traits that are in the pathway of causation between genetic variation and variation in risk of disease. The statistical strategy described in this paper is designed to aid geneticists and molecular biologists in their search to find the DNA sequences responsible for the genetic component of variation in these traits. With this information we will have a more complete understanding of the nature of the organization of the genetic variation responsible for quantitative variation in risk of disease. It will then be possible to fully evaluate the utility of measured genetic information in predicting the risk of common diseases having a complex multifactorial etiology, such as atherosclerosis and hypertension. | en_US |
dc.format.extent | 697674 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Gustav Fischer ; Springer Science+Business Media | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Public Health/Gesundheitswesen | en_US |
dc.subject.other | Cardiology | en_US |
dc.subject.other | Infectious Diseases | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Epidemiology | en_US |
dc.subject.other | Atherosclerosis | en_US |
dc.subject.other | Cladistics | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Application of cladistics to the analysis of genotype-phenotype relationships | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Medical Science II M4708, The University of Michigan Medical School, 48109-0618, ANN ARBOR, MI, USA | en_US |
dc.contributor.affiliationum | Medical Science II M4708, The University of Michigan Medical School, 48109-0618, ANN ARBOR, MI, USA | en_US |
dc.contributor.affiliationum | Medical Science II M4708, The University of Michigan Medical School, 48109-0618, ANN ARBOR, MI, USA | en_US |
dc.contributor.affiliationum | Medical Science II M4708, The University of Michigan Medical School, 48109-0618, ANN ARBOR, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 1354623 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42664/1/10654_2004_Article_BF00145343.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00145343 | en_US |
dc.identifier.source | European Journal of Epidemiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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