Human L1 retrotransposition: insights and peculiarities learned from a cultured cell retrotransposition assay
dc.contributor.author | Moran, John V. | en_US |
dc.date.accessioned | 2006-09-08T20:43:46Z | |
dc.date.available | 2006-09-08T20:43:46Z | |
dc.date.issued | 1999-11 | en_US |
dc.identifier.citation | Moran, John V.; (1999). "Human L1 retrotransposition: insights and peculiarities learned from a cultured cell retrotransposition assay." Genetica 107 (1-3): 39-51. <http://hdl.handle.net/2027.42/42793> | en_US |
dc.identifier.issn | 0016-6707 | en_US |
dc.identifier.issn | 1573-6857 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42793 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10952196&dopt=citation | en_US |
dc.description.abstract | Long Interspersed Nuclear Elements (L1s or LINEs) are the most abundant retrotransposons in the human genome, and they comprise approximately 17% of DNA. L1 retrotransposition can be mutagenic, and deleterious insertions both in the germ-line and in somatic cells have resulted in disease. Recently, an assay was developed to monitor L1 retrotransposition in cultured human cells. This assay, for the first time, now allows for a systematic study of L1 retrotransposition at the molecular level. Here, I will review progress made in L1 biology during the past three years. In general, I will limit the discussion to studies conducted on human L1s. However, interesting parallels to rodent L1s and other non-LTR retrotransposons also will be discussed. | en_US |
dc.format.extent | 140343 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Human Genetics | en_US |
dc.subject.other | Plant Genetics & Genomics | en_US |
dc.subject.other | Microbial Genetics and Genomics | en_US |
dc.subject.other | Animal Genetics and Genomics | en_US |
dc.subject.other | Cultured Cells | en_US |
dc.subject.other | LINE-1 | en_US |
dc.subject.other | Mutagen | en_US |
dc.subject.other | Retrotransposon | en_US |
dc.title | Human L1 retrotransposition: insights and peculiarities learned from a cultured cell retrotransposition assay | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Internal Medicine, The University of Michigan Medical School, Ann Arbor, MI, 48109-0618, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 10952196 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42793/1/10709_2004_Article_263353.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1004035023356 | en_US |
dc.identifier.source | Genetica | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.