Lack of effect of dihydroergotamine on endothelial and smooth muscle cell proliferation and endothelial cell prostanoid production
dc.contributor.author | Lindblad, Bengt | en_US |
dc.contributor.author | Burkel, William E. | en_US |
dc.contributor.author | Wakefield, Thomas W. | en_US |
dc.contributor.author | Graham, Linda M. | en_US |
dc.contributor.author | Stanley, James C. | en_US |
dc.date.accessioned | 2006-09-08T20:44:05Z | |
dc.date.available | 2006-09-08T20:44:05Z | |
dc.date.issued | 1988-03 | en_US |
dc.identifier.citation | Lindblad, B.; Burkel, W. E.; Wakefield, T. W.; Graham, L. M.; Stanley, J. C.; (1988). "Lack of effect of dihydroergotamine on endothelial and smooth muscle cell proliferation and endothelial cell prostanoid production." Experientia 44(3): 223-224. <http://hdl.handle.net/2027.42/42798> | en_US |
dc.identifier.issn | 0014-4754 | en_US |
dc.identifier.issn | 1420-9071 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42798 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3350133&dopt=citation | en_US |
dc.description.abstract | The most important effect of dihydroergotamine is venoconstriction, but certain metabolic effects and changes in vessel prostanoid activity have also been suggested. In this study endothelial cell production of 6-keto PGF 1α and TxB 2 was quantitated in vitro. No evidence of altered prostanoid production was noted after incubation with dihydroergotamine (exposure ranging from 5×10 −3 to 5×10 −7 g/l). Similarly, no effect of dihydroergotamine on the growth rates of endothelial cells or smooth muscle cells in vitro was documented. | en_US |
dc.format.extent | 267222 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Birkhäuser Verlag | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Biomedicine General | en_US |
dc.subject.other | Life Sciences, General | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Dihydroergotamine | en_US |
dc.subject.other | Endothelial Cells | en_US |
dc.subject.other | Smooth Muscle Cell | en_US |
dc.subject.other | Prostanoid Production | en_US |
dc.title | Lack of effect of dihydroergotamine on endothelial and smooth muscle cell proliferation and endothelial cell prostanoid production | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Surgery, University of Lund, Malmö General Hospital, S-21401, Malmö, Sweden | en_US |
dc.contributor.affiliationum | Department of Anatomy and Cell Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Anatomy and Cell Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3350133 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42798/1/18_2005_Article_BF01941713.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01941713 | en_US |
dc.identifier.source | Experientia | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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