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Triacylglycerol hydrolase: role in intracellular lipid metabolism
dc.contributor.authorDolinsky, V. W.en_US
dc.contributor.authorGilham, D.en_US
dc.contributor.authorAlam, M.en_US
dc.contributor.authorVance, D. E.en_US
dc.contributor.authorLehner, R.en_US
dc.date.accessioned2006-09-08T20:49:32Z
dc.date.available2006-09-08T20:49:32Z
dc.date.issued2004-06en_US
dc.identifier.citationDolinsky, V. W.; Gilham, D.; Alam, M.; Vance, D. E.; Lehner, R.; (2004). "Triacylglycerol hydrolase: role in intracellular lipid metabolism." Cellular and Molecular Life Sciences 61(13): 1633-1651. <http://hdl.handle.net/2027.42/42880>en_US
dc.identifier.issn1420-682Xen_US
dc.identifier.issn1420-9071en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/42880
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15224187&dopt=citationen_US
dc.description.abstractRecent scientific advances have revealed the identity of several enzymes involved in the synthesis, storage and catabolism of intracellular neutral lipid storage droplets. An enzyme that hydrolyzes stored triacylglycerol (TG), triacylglycerol hydrolase (TGH), was purified from porcine, human and murine liver microsomes. In rodents, TGH is highly expressed in liver as well as heart, kidney, small intestine and adipose tissues, while in humans TGH is mainly expressed in the liver, adipose and small intestine. TGH localizes to the endoplasmic reticulum and lipid droplets. The TGH genes are located within a cluster of carboxylesterase genes on human and mouse chromosomes 16 and 8, respectively. TGH hydrolyzes stored TG, and in the liver, the lipolytic products are made available for VLDL-TG synthesis. Inhibition of TGH activity also inhibits TG and apolipoprotein B secretion by primary hepatocytes. A role for TGH in basal TG lipolysis in adipocytes has been proposed. TGH expression and activity is both developmentally and hormonally regulated. A model for the function of TGH is presented and discussed with respect to tissue specific functions.en_US
dc.format.extent680922 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherBirkhäuser-Verlag; Birkhäuser-Verlag Basel ; Springer Science+Business Mediaen_US
dc.subject.otherLifeSciencesen_US
dc.subject.otherLipaseen_US
dc.subject.otherCarboxylesteraseen_US
dc.subject.otherTriacylglycerolen_US
dc.subject.otherVLDLen_US
dc.subject.otherLiveren_US
dc.subject.otherAdiposeen_US
dc.subject.otherAtherosclerosisen_US
dc.titleTriacylglycerol hydrolase: role in intracellular lipid metabolismen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbsecondlevelScience (General)en_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Pediatrics, Cell Biology and Biochemistry, CIHR Group on Molecular and Cell Biology of Lipids, University of Alberta, 328 Heritage Medical Research Centre, T6G 2S2, Edmonton, Alberta, Canada; Department of Physiology, University of Michigan, 48109-0622, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherDepartments of Pediatrics, Cell Biology and Biochemistry, CIHR Group on Molecular and Cell Biology of Lipids, University of Alberta, 328 Heritage Medical Research Centre, T6G 2S2, Edmonton, Alberta, Canadaen_US
dc.contributor.affiliationotherDepartments of Pediatrics, Cell Biology and Biochemistry, CIHR Group on Molecular and Cell Biology of Lipids, University of Alberta, 328 Heritage Medical Research Centre, T6G 2S2, Edmonton, Alberta, Canadaen_US
dc.contributor.affiliationotherDepartments of Pediatrics, Cell Biology and Biochemistry, CIHR Group on Molecular and Cell Biology of Lipids, University of Alberta, 328 Heritage Medical Research Centre, T6G 2S2, Edmonton, Alberta, Canadaen_US
dc.contributor.affiliationotherDepartments of Pediatrics, Cell Biology and Biochemistry, CIHR Group on Molecular and Cell Biology of Lipids, University of Alberta, 328 Heritage Medical Research Centre, T6G 2S2, Edmonton, Alberta, Canadaen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid15224187en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/42880/1/018_2004_Article_3426.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00018-004-3426-3en_US
dc.identifier.sourceCellular and Molecular Life Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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