Leptin receptor action and mechanisms of leptin resistance

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dc.contributor.author Münzberg, H. en_US
dc.contributor.author Björnholm, M. en_US
dc.contributor.author Bates, S. H. en_US
dc.contributor.author Myers, M. G. en_US
dc.date.accessioned 2006-09-08T20:50:04Z
dc.date.available 2006-09-08T20:50:04Z
dc.date.issued 2005-03 en_US
dc.identifier.citation Münzberg, H.; Björnholm, M.; Bates, S. H.; Myers, M. G.; (2005). "Leptin receptor action and mechanisms of leptin resistance." CMLS Cellular and Molecular Life Sciences 62(6): 642-652. <http://hdl.handle.net/2027.42/42888> en_US
dc.identifier.issn 1420-682X en_US
dc.identifier.issn 1420-9071 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/42888
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15770417&dopt=citation en_US
dc.description.abstract The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these signals play in leptin action in vivo. Furthermore, we discuss potential mechanisms of leptin resistance, specifically focusing on data regarding the neuroanatomical locus of leptin resistance and potential mechanisms by which expression of the suppressor of cytokine signaling-3 may impair leptin action. en_US
dc.format.extent 191659 bytes
dc.format.extent 3115 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Birkhäuser-Verlag; Birkhäuser Verlag, Basel ; Springer Science+Business Media en_US
dc.subject.other Life Sciences en_US
dc.subject.other Biomedicine General en_US
dc.subject.other Life Sciences, General en_US
dc.subject.other Biochemistry, General en_US
dc.subject.other Cell Biology en_US
dc.subject.other Leptin en_US
dc.subject.other Obesity en_US
dc.subject.other SOCS3 en_US
dc.subject.other Signaling en_US
dc.subject.other Arcuate Nucleus en_US
dc.subject.other Hypothalamus en_US
dc.title Leptin receptor action and mechanisms of leptin resistance en_US
dc.type Review en_US
dc.subject.hlbsecondlevel Ecology and Evolutionary Biology en_US
dc.subject.hlbsecondlevel Science (General) en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Division of Metabolism, Endocrinology and Diabetes, Departments of Internal Medicine and Molecular and Physiology, University of Michigan Medical School, 1150 W. Medical Center Dr., 4301 MSRB 3, Box 0638, Ann Arbor, Michigan, 48109-0638, USA en_US
dc.contributor.affiliationum Division of Metabolism, Endocrinology and Diabetes, Departments of Internal Medicine and Molecular and Physiology, University of Michigan Medical School, 1150 W. Medical Center Dr., 4301 MSRB 3, Box 0638, Ann Arbor, Michigan, 48109-0638, USA en_US
dc.contributor.affiliationum Division of Metabolism, Endocrinology and Diabetes, Departments of Internal Medicine and Molecular and Physiology, University of Michigan Medical School, 1150 W. Medical Center Dr., 4301 MSRB 3, Box 0638, Ann Arbor, Michigan, 48109-0638, USA en_US
dc.contributor.affiliationum Division of Metabolism, Endocrinology and Diabetes, Departments of Internal Medicine and Molecular and Physiology, University of Michigan Medical School, 1150 W. Medical Center Dr., 4301 MSRB 3, Box 0638, Ann Arbor, Michigan, 48109-0638, USA en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 15770417 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/42888/1/18_2004_Article_4432.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1007/s00018-004-4432-1 en_US
dc.identifier.source CMLS Cellular and Molecular Life Sciences en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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