Tibialis anterior muscles in mdx mice are highly susceptible to contraction-induced injury
dc.contributor.author | Dellorusso, Christiana | en_US |
dc.contributor.author | Crawford, Robert W. | en_US |
dc.contributor.author | Chamberlain, Jeffrey S. | en_US |
dc.contributor.author | Brooks, Susan V. | en_US |
dc.date.accessioned | 2006-09-08T21:07:16Z | |
dc.date.available | 2006-09-08T21:07:16Z | |
dc.date.issued | 2001-07 | en_US |
dc.identifier.citation | Dellorusso, Christiana; Crawford, Robert W.; Chamberlain, Jeffrey S.; Brooks, Susan V.; (2001). "Tibialis anterior muscles in mdx mice are highly susceptible to contraction-induced injury." Journal of Muscle Research and Cell Motility 22(5): 467-475. <http://hdl.handle.net/2027.42/43148> | en_US |
dc.identifier.issn | 0142-4319 | en_US |
dc.identifier.issn | 1573-2657 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/43148 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11964072&dopt=citation | en_US |
dc.description.abstract | Skeletal muscles of patients with Duchenne muscular dystrophy (DMD) and mdx mice lack dystrophin and are more susceptible to contraction-induced injury than control muscles. Our purpose was to develop an assay based on the high susceptibility to injury of limb muscles in mdx mice for use in evaluating therapeutic interventions. The assay involved two stretches of maximally activated tibialis anterior (TA) muscles in situ . Stretches of 40% strain relative to muscle fiber length were initiated from the plateau of isometric contractions. The magnitude of damage was assessed one minute later by the deficit in isometric force. At all ages (2–19 months), force deficits were four- to seven-fold higher for muscles in mdx compared with control mice. For control muscles, force deficits were unrelated to age, whereas force deficits increased dramatically for muscles in mdx mice after 8 months of age. The increase in susceptibility to injury of muscles from older mdx mice did not parallel similar adverse effects on muscle mass or force production. The in situ stretch protocol of TA muscles provides a valuable assay for investigations of the mechanisms of injury in dystrophic muscle and to test therapeutic interventions for reversing DMD. | en_US |
dc.format.extent | 706940 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Biomedicine General | en_US |
dc.subject.other | Proteomics | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Animal Anatomy / Morphology / Histology | en_US |
dc.title | Tibialis anterior muscles in mdx mice are highly susceptible to contraction-induced injury | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Kinesiology and Sports | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, 300 North Ingalls Building, Ann Arbor, Michigan, 48109-2007, USA; Department of Physiology, University of Michigan, 300 North Ingalls Building, Ann Arbor, Michigan, 48109-2007, USA; Department of Neurology, University of Washington, Seattle, WA, 98195-7720 | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, 300 North Ingalls Building, Ann Arbor, Michigan, 48109-2007, USA; Department of Neurology, University of Washington, Seattle, WA, 98195-7720 | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, 300 North Ingalls Building, Ann Arbor, Michigan, 48109-2007, USA; Department of Neurology, University of Washington, Seattle, WA, 98195-7720 | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, 300 North Ingalls Building, Ann Arbor, Michigan, 48109-2007, USA; Institute of Gerontology, University of Michigan, 300 North Ingalls Building, Ann Arbor, Michigan, 48109-2007, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 11964072 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/43148/1/10974_2004_Article_390575.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1014587918367 | en_US |
dc.identifier.source | Journal of Muscle Research and Cell Motility | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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