High density peptide microarrays. In situ synthesis and applications
dc.contributor.author | Gao, Xiaolian | en_US |
dc.contributor.author | Pellois, Jean Philippe | en_US |
dc.contributor.author | Na, Younghwa | en_US |
dc.contributor.author | Kim, Younkee | en_US |
dc.contributor.author | Gulari, Erdogan | en_US |
dc.contributor.author | Zhou, Xiaochuan | en_US |
dc.date.accessioned | 2006-09-08T21:13:49Z | |
dc.date.available | 2006-09-08T21:13:49Z | |
dc.date.issued | 2004-09 | en_US |
dc.identifier.citation | Gao, Xiaolian; Pellois, Jean Philippe; Na, Younghwa; Kim, Younkee; Gulari, Erdogan; Zhou, Xiaochuan; (2004). "High density peptide microarrays. In situ synthesis and applications." Molecular Diversity 8(3): 177-187. <http://hdl.handle.net/2027.42/43247> | en_US |
dc.identifier.issn | 1381-1991 | en_US |
dc.identifier.issn | 1573-501X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/43247 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15384411&dopt=citation | en_US |
dc.description.abstract | The technologies enabling the creation of large scale, miniaturized peptide or protein microarrays are emerging. The focuses of this review are the synthesis and applications of peptide and peptidomimetic microarrays, especially the light directed parallel synthesis of individually addressable high density peptide microarrays using a novel photogenerated reagent chemistry and digital photolithography (Gao et al., 1998, J. Am. Chem. Soc. 120, 12698; Pellois et al. 2002, Nat. Biotechnol. 20, 922). Concepts related to the synthesis are discussed, such as the reactions of photogenerated acids in the deprotection step of peptide synthesis or oligonucleotide synthesis, and the applications of high density peptide chips in antibody binding assays are discussed. Peptide chips provide versatile tools for probing antigen-antibody, protein-protein, peptide-ligand interactions and are basic components for miniaturization, automation, and system integration in research and clinical diagnosis applications. | en_US |
dc.format.extent | 242327 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Analytical Chemistry | en_US |
dc.subject.other | Organic Chemistry | en_US |
dc.subject.other | Polymer Sciences | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Antibody Binding | en_US |
dc.subject.other | Digital Photolithography | en_US |
dc.subject.other | Epitope Screening | en_US |
dc.subject.other | Miniaturization | en_US |
dc.subject.other | Parallel Synthesis | en_US |
dc.subject.other | Peptide Chip | en_US |
dc.subject.other | Peptide Microarray | en_US |
dc.subject.other | PGA | en_US |
dc.subject.other | PGR Chemistry | en_US |
dc.subject.other | Protein Binding Assay | en_US |
dc.title | High density peptide microarrays. In situ synthesis and applications | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109 | en_US |
dc.contributor.affiliationother | Department of Chemistry, University of Houston, Houston, TX, 77004-5003 | en_US |
dc.contributor.affiliationother | Department of Chemistry, University of Houston, Houston, TX, 77004-5003 | en_US |
dc.contributor.affiliationother | Department of Chemistry, University of Houston, Houston, TX, 77004-5003 | en_US |
dc.contributor.affiliationother | Xeotron Co, 8275 El Rio, Suite 130, Houston, TX, 77054 | en_US |
dc.contributor.affiliationother | Atactic Technologies Inc., 2572 West Belfort, Houston, TX, 77054 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15384411 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/43247/1/11030_2004_Article_5263634.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/B:MODI.0000036233.58271.25 | en_US |
dc.identifier.source | Molecular Diversity | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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