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Growth conditions of F9 embryonal carcinoma cells affect the degree of DNA methylation
dc.contributor.authorErickson, Robert P.en_US
dc.contributor.authorFerrucci, S.en_US
dc.contributor.authorRahe, B.en_US
dc.contributor.authorRosenberg, Michael P.en_US
dc.contributor.authorMorello, D.en_US
dc.date.accessioned2006-09-08T21:13:53Z
dc.date.available2006-09-08T21:13:53Z
dc.date.issued1984-12en_US
dc.identifier.citationErickson, R. P.; Ferrucci, S.; Rahe, B.; Rosenberg, M. P.; Morello, D.; (1984). "Growth conditions of F9 embryonal carcinoma cells affect the degree of DNA methylation." Molecular Biology Reports 10(2): 109-113. <http://hdl.handle.net/2027.42/43248>en_US
dc.identifier.issn0301-4851en_US
dc.identifier.issn1573-4978en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/43248
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6098808&dopt=citationen_US
dc.description.abstractWe have investigated differences in C * pG methylation between F9 embryonal carcinoma cells in vitro and as tumor cells grown in vivo using Msp I and Hpa II restriction isoschizomers. Southerns were hybridized with two low copy number probes, mouse major β-globin (f7) and a class I, histocompatibility-2 cDNA clone (pH-2 d -4). In each case, the tumor-DNA was hypomethylated while the DNA from F9 cells grown in vitro was moderately methylated. We conclude that growth conditions or cell-cell interactions can greatly affect methylation of C * pG sites.en_US
dc.format.extent811933 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers; Dr W. Junk Publishers ; Springer Science+Business Mediaen_US
dc.subject.otherLife Sciencesen_US
dc.subject.otherAnimal Biochemistryen_US
dc.subject.otherAnimal Anatomy / Morphology / Histologyen_US
dc.titleGrowth conditions of F9 embryonal carcinoma cells affect the degree of DNA methylationen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan School of Medicine, Box 015, Ann Arbor, Mich., USA; Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, P.O. Box no. 123, WC2A 3PX, London, Great Britainen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan School of Medicine, Box 015, Ann Arbor, Mich., USA; Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, P.O. Box no. 123, WC2A 3PX, London, Great Britainen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan School of Medicine, Box 015, Ann Arbor, Mich., USA; Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, P.O. Box no. 123, WC2A 3PX, London, Great Britainen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan School of Medicine, Box 015, Ann Arbor, Mich., USA; Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, P.O. Box no. 123, WC2A 3PX, London, Great Britainen_US
dc.contributor.affiliationotherDépartement de Biologie Moleculaire, Institut Pasteur, 75024, Paris, Franceen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid6098808en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/43248/1/11033_2004_Article_BF00776983.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00776983en_US
dc.identifier.sourceMolecular Biology Reportsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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