Structure-function analysis in nuclear RNase P RNA
dc.contributor.author | Tranguch, Anthony J. | en_US |
dc.contributor.author | Engelke, David R. | en_US |
dc.contributor.author | Pagán-Ramos, Eileen | en_US |
dc.date.accessioned | 2006-09-08T21:14:09Z | |
dc.date.available | 2006-09-08T21:14:09Z | |
dc.date.issued | 1995-06 | en_US |
dc.identifier.citation | Engelke, David R.; Pagán-Ramos, Eileen; Tranguch, Anthony J.; (1995). "Structure-function analysis in nuclear RNase P RNA." Molecular Biology Reports 22 (2-3): 157-160. <http://hdl.handle.net/2027.42/43252> | en_US |
dc.identifier.issn | 0301-4851 | en_US |
dc.identifier.issn | 1573-4978 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/43252 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8901504&dopt=citation | en_US |
dc.description.abstract | Eukaryotic ribonuclease P (RNase P) enzymes require both RNA and protein subunits for activity in vivo and in vitro . We have undertaken an analysis of the complex RNA subunit of the nuclear holoenzyme in an effort to understand its structure and its similarities to and differences from the bacterial ribozymes. Phylogenetic analysis, structure-sensitive RNA footprinting, and directed mutagenesis reveal conserved secondary and tertiary structures with both strong similarities to the bacterial consensus and distinctive features. The effects of mutations in the most highly conserved positions are being used to dissect the functions of individual subdomains. | en_US |
dc.format.extent | 486161 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Animal Biochemistry | en_US |
dc.subject.other | Animal Anatomy / Morphology / Histology | en_US |
dc.subject.other | Nuclear | en_US |
dc.subject.other | RNase P | en_US |
dc.subject.other | RNA Structure | en_US |
dc.subject.other | Yeast | en_US |
dc.title | Structure-function analysis in nuclear RNase P RNA | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan, 48109-0606, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan, 48109-0606, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan, 48109-0606, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8901504 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/43252/1/11033_2004_Article_BF00988722.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00988722 | en_US |
dc.identifier.source | Molecular Biology Reports | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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