The fungicidal activity of novel nanoemulsion (X8W 60 PC) against clinically important yeast and filamentous fungi
dc.contributor.author | Myc, Andrzej | en_US |
dc.contributor.author | Vanhecke, Thomas | en_US |
dc.contributor.author | Landers, Jeffrey J. | en_US |
dc.contributor.author | Hamouda, Tarek | en_US |
dc.contributor.author | Baker, James R. Jr. | en_US |
dc.date.accessioned | 2006-09-08T21:15:33Z | |
dc.date.available | 2006-09-08T21:15:33Z | |
dc.date.issued | 2003-05 | en_US |
dc.identifier.citation | Myc, Andrzej; Vanhecke, Thomas; Landers, Jeffrey J.; Hamouda, Tarek; Baker, James R.; (2003). "The fungicidal activity of novel nanoemulsion (X8W 60 PC) against clinically important yeast and filamentous fungi." Mycopathologia 155(4): 195-201. <http://hdl.handle.net/2027.42/43273> | en_US |
dc.identifier.issn | 0301-486X | en_US |
dc.identifier.issn | 1573-0832 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/43273 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12650595&dopt=citation | en_US |
dc.description.abstract | Surfactant nanoemulsions are water in oil preparations that proved to have a broad spectrum biocidal activity against a variety of microorganisms including Gram-positive and Gram-negative bacteria, spores and enveloped viruses. These preparations are non-toxic to the skin, mucous membrane and gastrointestinal tissues at biocidal concentrations. In this study, 0.1% of the nanoemulsion designated X8W 60 PC has shown fungicidal activity against yeast including Candida albicans and C. tropicalis in 15 minutes. C. tropicalis was more sensitive than C. albicans , which required a longer time or a higher concentration of the nanoemulsion to achieve killing. Neutral to slightly alkaline pH was more effective in killing the yeast cells than acidic pH. Using the minimum inhibitory concentration assay, 0.08% of the nanoemulsion was inhibitory to C. albicans , and parapsilosis and filamentous fungi including Microsporum gypseum , Trichophyton mentagrophytes , Trichophyton rubrum , Aspergillus fumigatus and Fusarium oxysporum .None of the individual ingredients was as effective a fungicidal as the nanoemulsion at equivalent concentration. This shows that the nanoemulsion structure is an important factor in the anti-fungal activity. The X8W 60 PC has great potential as a topical anti-fungal agent and further investigation into the mechanism of fungicidal action is warranted. | en_US |
dc.format.extent | 619848 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.subject.other | Microbial Ecology | en_US |
dc.subject.other | Microbiology | en_US |
dc.subject.other | Plant Sciences | en_US |
dc.subject.other | Nanoemulsion | en_US |
dc.subject.other | Fungicidal | en_US |
dc.subject.other | Topical Treatment | en_US |
dc.subject.other | Yeast | en_US |
dc.subject.other | Filamentous Fungi | en_US |
dc.subject.other | Disinfectant | en_US |
dc.title | The fungicidal activity of novel nanoemulsion (X8W 60 PC) against clinically important yeast and filamentous fungi | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Allergy and Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Allergy and Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Allergy and Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Allergy and Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | NanoBio Corporation, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 12650595 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/43273/1/11046_2004_Article_5096122.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1021129710316 | en_US |
dc.identifier.source | Mycopathologia | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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