Mycobacterium avium Subspecies Paratuberculosis in the Inflamed Gut Tissues of Patients with Crohn’s Disease in China and its Potential Relationship to the Consumption of Cow’s Milk: A Preliminary Study
dc.contributor.author | Hermon-Taylor, J. | en_US |
dc.contributor.author | Bull, T. J. | en_US |
dc.contributor.author | Cheng, J. | en_US |
dc.contributor.author | Dalton, P. | en_US |
dc.contributor.author | Cen, S. | en_US |
dc.contributor.author | Finlayson, C. | en_US |
dc.date.accessioned | 2006-09-11T14:01:29Z | |
dc.date.available | 2006-09-11T14:01:29Z | |
dc.date.issued | 2005-10 | en_US |
dc.identifier.citation | Cheng, J.; Bull, T. J.; Dalton, P.; Cen, S.; Finlayson, C.; Hermon-Taylor, J.; (2005). " Mycobacterium avium Subspecies Paratuberculosis in the Inflamed Gut Tissues of Patients with Crohn’s Disease in China and its Potential Relationship to the Consumption of Cow’s Milk: A Preliminary Study." World Journal of Microbiology and Biotechnology 21 (6-7): 1175-1179. <http://hdl.handle.net/2027.42/43919> | en_US |
dc.identifier.issn | 0959-3993 | en_US |
dc.identifier.issn | 1573-0972 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/43919 | |
dc.description.abstract | Mycobacterium avium subspecies paratuberculosis infection in domestic livestock is widespread in many countries throughout the world. Studies in Europe and the USA show that M. avium subspecies paratuberculosis can be cultured from retail pasteurized cow’s milk and that these organisms are being transmitted to humans by this route. Most people with chronic inflammation of the intestine of the Crohn’s disease type are infected with these chronic enteric pathogens. The production and consumption of cow’s milk has increased in China and so also has the incidence of Crohn’s disease. The present preliminary investigation was carried out to determine whether M. avium subspecies paratuberculosis is present in the intestinal tissues of Chinese patients with Crohn’s disease who have never left China. Archival paraffin-embedded surgical pathology blocks from patients having surgery for Crohn’s disease (CD) or for cancer (nIBD) in China were studied. M. avium subspecies paratuberculosis was detected by nested IS 900 PCR with Southern blotting and amplicon sequencing. The intestinal tissues of 9 of 13 (69.2%) CD patients and 2 of 14 (14.3%) nIBD patients were IS 900 PCR positive ( P = 0.0063; odds ratio = 13.5). These initial studies suggest that people in China are exposed to M. avium subspecies paratuberculosis and that as in other countries, the infection is significantly associated with Crohn’s disease. M. avium subspecies paratuberculosis in dairy herds and retail milk in China needs to be investigated. | en_US |
dc.format.extent | 268437 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer | en_US |
dc.subject.other | Biotechnology | en_US |
dc.subject.other | Applied Microbiology | en_US |
dc.subject.other | Microbiology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | China | en_US |
dc.subject.other | Crohn’S Disease | en_US |
dc.subject.other | Dairy Products | en_US |
dc.subject.other | Food Safety | en_US |
dc.subject.other | Infection | en_US |
dc.subject.other | Inflammatory Bowel Disease | en_US |
dc.subject.other | Mycobacterium Avium Subspecies Paratuberculosis | en_US |
dc.subject.other | Pasteurization | en_US |
dc.subject.other | Zoonosis | en_US |
dc.subject.other | Johne’S Disease | en_US |
dc.subject.other | Environmental Biotechnology | en_US |
dc.subject.other | Chemistry | en_US |
dc.title | Mycobacterium avium Subspecies Paratuberculosis in the Inflamed Gut Tissues of Patients with Crohn’s Disease in China and its Potential Relationship to the Consumption of Cow’s Milk: A Preliminary Study | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, St. George’s Hospital Medical School, London, SW17 ORE, UK; General Surgery, TC-2926D, University of Michigan Health System, 1500 E. Medical Center Dr., Ann Arbor, 48109, MI, USA | en_US |
dc.contributor.affiliationother | Department of Surgery, St. George’s Hospital Medical School, London, SW17 ORE, UK | en_US |
dc.contributor.affiliationother | Department of Histopathology, St. George’s Hospital Medical School, London, SW17 ORE, UK | en_US |
dc.contributor.affiliationother | Department of Surgery, St. George’s Hospital Medical School, London, SW17 ORE, UK; Department of Digestion, Affiliated Hospital to Ningxia Medical University, 78 South Shengli Road, Yinchuan, Ningxia, 750004, China | en_US |
dc.contributor.affiliationother | Department of Histopathology, St. George’s Hospital Medical School, London, SW17 ORE, UK | en_US |
dc.contributor.affiliationother | Department of Surgery, St. George’s Hospital Medical School, London, SW17 ORE, UK | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/43919/1/11274_2005_Article_0809.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s11274-005-0809-z | en_US |
dc.identifier.source | World Journal of Microbiology and Biotechnology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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