Predicting oral anticoagulant response using a pharmacodynamic model
dc.contributor.author | Abbrecht, Peter Herman | en_US |
dc.contributor.author | O'Leary, Timothy J. | en_US |
dc.date.accessioned | 2006-09-11T14:09:04Z | |
dc.date.available | 2006-09-11T14:09:04Z | |
dc.date.issued | 1981-05 | en_US |
dc.identifier.citation | O'Leary, Timothy J.; Abbrecht, Peter H.; (1981). "Predicting oral anticoagulant response using a pharmacodynamic model." Annals of Biomedical Engineering 9(3): 199-216. <http://hdl.handle.net/2027.42/44006> | en_US |
dc.identifier.issn | 1573-9686 | en_US |
dc.identifier.issn | 0090-6964 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44006 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7337276&dopt=citation | en_US |
dc.description.abstract | We developed a pharmacokinetic and pharmacodynamic model of warfarin absorption, metabolism, and anticoagulant action appropriate for guiding anticoagulant therapy. The model requires only two independently adjustable parameters to describe warfarin's effect on individual patients. For any given individual, these parameters are rapidly and inexpensively identified using a computer program based on the model. Test data were generated by superimposing Gaussian noise on dose-response curves calculated with the model. Then the computer program was applied to the test data. Future prothrombin complex activities (PCA's) and maintenance doses were predicted accurately early in the course of drug administration. In addition, the program accurately predicted PCA response in two groups of normal volunteers. | en_US |
dc.format.extent | 907933 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Pergamon Press Ltd. and Biomedical Engineering Society ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Mechanics | en_US |
dc.subject.other | Biomedicine General | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Biophysics/Biomedical Physics | en_US |
dc.title | Predicting oral anticoagulant response using a pharmacodynamic model | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan Medical School, Ann Arbor, Michigan; Laboratory of Pathology, National Cancer Institute, Building 10, Room 1A 24, 20205, Bethesda, Maryland | en_US |
dc.contributor.affiliationum | Departments of Physiology and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan; Departments of Physiology and Internal Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7337276 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44006/1/10439_2006_Article_BF02363455.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02363455 | en_US |
dc.identifier.source | Annals of Biomedical Engineering | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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