Epistasis among Presynaptic Serotonergic System Components
dc.contributor.author | Stoltenberg, Scott F. | en_US |
dc.date.accessioned | 2006-09-11T14:18:21Z | |
dc.date.available | 2006-09-11T14:18:21Z | |
dc.date.issued | 2005-03 | en_US |
dc.identifier.citation | Stoltenberg, Scott F.; (2005). "Epistasis among Presynaptic Serotonergic System Components." Behavior Genetics 35(2): 199-209. <http://hdl.handle.net/2027.42/44113> | en_US |
dc.identifier.issn | 0001-8244 | en_US |
dc.identifier.issn | 1573-3297 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44113 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15685432&dopt=citation | en_US |
dc.description.abstract | Epistatic interactions among regulatory components of the serotonin (5-HT) neurotransmitter system may be an important aspect of 5-HT function. Because 5-HT dysregulation is associated with several common psychiatric disorders, the potential for epistasis among genetic variants in the 5-HT transporter (SERT), 5-HT 1B terminal autoreceptor and the 5-HT 1A somatodendritic autoreceptor should be examined. In this study, output from a dynamic minimal model of 5-HT function was compared to empirical results in the literature. Parameters representing extracellular 5-HT clearance rates (SERT), 5-HT release levels (5-HT 1B ) and inhibitory thresholds (the amount of extracellular 5-HT above which cell firing is inhibited, an indication of 5-HT 1A autoreceptor sensitivity) were varied to simulate genetic deletion (i.e. knockout) of each component singly, and in combination. Simulated knockout effects on extracellular 5-HT level and presynaptic neural firing rates were in the same direction and of similar relative magnitude as studies in the literature. Epistasis among presynaptic components appears to be important in the 5-HT system’s regulation of extracellular 5-HT levels, but not of firing rates. | en_US |
dc.format.extent | 295235 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc. | en_US |
dc.subject.other | 5-HT 1B | en_US |
dc.subject.other | Knockout | en_US |
dc.subject.other | Dynamic Systems | en_US |
dc.subject.other | Epistasis | en_US |
dc.subject.other | Serotonin | en_US |
dc.subject.other | SERT | en_US |
dc.subject.other | 5-HT 1A | en_US |
dc.title | Epistasis among Presynaptic Serotonergic System Components | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan Addiction Research Center, 2025 Traverwood, Suite A, Ann Arbor, Michigan, 48105-2194; Department of Psychology, Black Hills State University, 1200 University Street, Unit 9129, Spearfish, South Dakota, 57799-9129; Department of Psychology, Black Hills State University, 1200 University Street, Unit 9129, Spearfish, South Dakota, 57799-9129 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15685432 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44113/1/10519_2004_Article_1019.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s10519-004-1019-4 | en_US |
dc.identifier.source | Behavior Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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