Association between cholesterol and 2,3-diphosphoglycerate in genetically selected hooded rat lines
dc.contributor.author | Noble, Nancy A. | en_US |
dc.contributor.author | Brewer, George J. | en_US |
dc.contributor.author | Oelshlegel, F. J. | en_US |
dc.date.accessioned | 2006-09-11T14:19:35Z | |
dc.date.available | 2006-09-11T14:19:35Z | |
dc.date.issued | 1978-02 | en_US |
dc.identifier.citation | Noble, N. A.; Brewer, G. J.; Oelshlegel, F. J.; (1978). "Association between cholesterol and 2,3-diphosphoglycerate in genetically selected hooded rat lines." Biochemical Genetics 16 (1-2): 39-44. <http://hdl.handle.net/2027.42/44127> | en_US |
dc.identifier.issn | 0006-2928 | en_US |
dc.identifier.issn | 1573-4927 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44127 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=646785&dopt=citation | en_US |
dc.description.abstract | We have developed two strains of hooded rats with differing erythrocyte oxygen affinities by selection on red cell 2,3-diphosphoglycerate levels. Genetic studies have shown that these strains differ at one DPG-level-determining locus. This article reports the results of a study which involved measurement of plasma cholesterol levels in rats from the strains and the F 2 progeny of strain intercrosses. Low-DPG strain rats, with high oxygen affinity, had significantly higher mean cholesterol levels than High-DPG rats. Animals from the extremes of the F 2 distribution of DPG levels showed similar, significantly different mean cholesterol levels, indicating that the negative association between DPG and cholesterol levels in strain rats was not due to inadvertent fixation of unrelated genes during selection on DPG. The possibility is discussed that high oxygen affinity, brought about by low DPG levels, may be causative in increasing cholesterol levels. | en_US |
dc.format.extent | 323666 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | 2,3-diphosphoglycerate | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Human Genetics | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Zoology | en_US |
dc.subject.other | Cholesterol | en_US |
dc.subject.other | Oxygen Affinity | en_US |
dc.subject.other | Hooded Rats | en_US |
dc.title | Association between cholesterol and 2,3-diphosphoglycerate in genetically selected hooded rat lines | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, Michigan; Department of Medicine, Harbor General Hospital, 90502, Torrance, California | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, Michigan; Department of Preventive Medicine, University of Mississippi, 39216, Jackson, Mississippi | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 646785 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44127/1/10528_2004_Article_BF00484383.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00484383 | en_US |
dc.identifier.source | Biochemical Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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