Fluoride inhibition in patients with atypical dibucaine-resistant plasmacholinesterase
dc.contributor.author | Kothary, Sarla P. | en_US |
dc.contributor.author | Flynn, Kathleen B. | en_US |
dc.contributor.author | Zsigmond, Elemér K. | en_US |
dc.date.accessioned | 2006-09-11T14:19:55Z | |
dc.date.available | 2006-09-11T14:19:55Z | |
dc.date.issued | 1979-12 | en_US |
dc.identifier.citation | Kothary, Sarla P.; Flynn, Kathleen B.; Zsigmond, Elemér K.; (1979). "Fluoride inhibition in patients with atypical dibucaine-resistant plasmacholinesterase." Biochemical Genetics 17 (11-12): 1169-1172. <http://hdl.handle.net/2027.42/44131> | en_US |
dc.identifier.issn | 0006-2928 | en_US |
dc.identifier.issn | 1573-4927 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44131 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=540007&dopt=citation | en_US |
dc.description.abstract | The fluoride numbers (FN) of 144 individuals referred to our laboratory for dibucaine number (DN) determinations because of prolonged apnea following succinylcholine in the probands or relatives were determined by our new method using 2.5×10 −4 M concentration of sodium fluoride at 37 C. Dibucaine-resistant homozygotes and heterozygotes both had lower FN than the normal homozygotes. A linear correlation between DN and FN for all these genotypes was found which is described by the equation FN=0.59DN+32. The correlation coefficient was r=0.94. This equation will help in the correct identification of atypical fluoride resistant genotypes, since these ought to have an observed FN lower by 2 standard deviations than the FN calculated from this equation. | en_US |
dc.format.extent | 214582 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Zoology | en_US |
dc.subject.other | Human Genetics | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | FN-DN Correlation | en_US |
dc.subject.other | Fluoride-resistant Plasmacholinesterase, Dibucaine-resistant Plasmacholinesterase | en_US |
dc.subject.other | Biomedicine | en_US |
dc.title | Fluoride inhibition in patients with atypical dibucaine-resistant plasmacholinesterase | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan Medical Center, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 540007 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44131/1/10528_2004_Article_BF00504354.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00504354 | en_US |
dc.identifier.source | Biochemical Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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