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Chemical characterization of a new Japanese variant of carbonic anhydrase I, CA I Nagasaki 1 (76 Arg→Gln)
dc.contributor.authorHenriksson, Dag M.en_US
dc.contributor.authorStroup, Sharon K.en_US
dc.contributor.authorGoriki, Kazuakien_US
dc.contributor.authorTashian, Richard E.en_US
dc.contributor.authorYu, Ya-Shiou L.en_US
dc.date.accessioned2006-09-11T14:20:01Z
dc.date.available2006-09-11T14:20:01Z
dc.date.issued1979-06en_US
dc.identifier.citationGoriki, Kazuaki; Tashian, Richard E.; Stroup, Sharon K.; Yu, Ya-Shiou L.; Henriksson, Dag M.; (1979). "Chemical characterization of a new Japanese variant of carbonic anhydrase I, CA I Nagasaki 1 (76 Arg→Gln)." Biochemical Genetics 17 (5-6): 449-460. <http://hdl.handle.net/2027.42/44132>en_US
dc.identifier.issn0006-2928en_US
dc.identifier.issn1573-4927en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44132
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=117793&dopt=citationen_US
dc.description.abstractA new inherited variant of carbonic anhydrase I (CA I), designated CA I Nagasaki 1 (CA I NGS 1 ), was discovered during a survey of hemolysates from 5852 individuals from the cities of Hiroshima and Nagasaki in Japan. Analysis of the amino acid composition of a tryptic peptide from the CA I NGS 1 variant indicated that a glutaminyl residue was substituted for an arginyl residue at position 76. Heat degradation studies showed that the CA I NGS 1 variant was less stable than normal CA I. The CO 2 hydrase and esterase activities of the normal and variant carbonic anhydrases I, as well as the relative amounts of the two enzymes in heterozygotes, were similar.en_US
dc.format.extent526177 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherZoologyen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherThermostabilityen_US
dc.subject.otherHuman Geneticsen_US
dc.subject.otherMedical Microbiologyen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherRed Cell Carbonic Anhydrase Ien_US
dc.subject.otherNew Japanese Varianten_US
dc.subject.otherAmino Acid Substitutionen_US
dc.subject.otherCO 2 Hydrase and Esterase Activitiesen_US
dc.titleChemical characterization of a new Japanese variant of carbonic anhydrase I, CA I Nagasaki 1 (76 Arg→Gln)en_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, Michigan; Clinical Laboratories, Radiation Effects Research Foundation, 730, Hiroshima, Japanen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, Michigan; Department of Biochemistry, University of Göteborg, Göteborg, 5, Swedenen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid117793en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44132/1/10528_2004_Article_BF00498883.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00498883en_US
dc.identifier.sourceBiochemical Geneticsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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