Characterization of human lymphocyte N -acetyltransferase and its relationship to the isoniazid acetylator polymorphism
dc.contributor.author | McQueen, Charlene A. | en_US |
dc.contributor.author | Weber, Wendell W. | en_US |
dc.date.accessioned | 2006-09-11T14:20:27Z | |
dc.date.available | 2006-09-11T14:20:27Z | |
dc.date.issued | 1980-10 | en_US |
dc.identifier.citation | McQueen, Charlene A.; Weber, Wendell W.; (1980). "Characterization of human lymphocyte N -acetyltransferase and its relationship to the isoniazid acetylator polymorphism." Biochemical Genetics 18 (9-10): 889-904. <http://hdl.handle.net/2027.42/44137> | en_US |
dc.identifier.issn | 0006-2928 | en_US |
dc.identifier.issn | 1573-4927 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44137 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7225085&dopt=citation | en_US |
dc.description.abstract | Characterization of human lymphocyte N -acetyltransferase (NAT) for specific activity, substrate specificity, inhibition, pH optimum, apparent K m , kinetic mechanism, trypsin stability, freezing stability, and heat stability was carried out in rapid and slow isoniazid (INH) acetylators. There is a statistically significant difference in the heat stability of lymphocyte NAT from rapid and slow INH phenotypes. The lymphocyte enzyme from rapid INH acetylators is less heat stable than the lymphocyte enzyme from slow INH acetylators. This is an indication of a structural, possibly polymorphic, difference in lymphocyte NAT from the two acetylator phenotypes. | en_US |
dc.format.extent | 721964 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Zoology | en_US |
dc.subject.other | Isoniazid Acetylator Polymorphism | en_US |
dc.subject.other | Heat Stability | en_US |
dc.subject.other | N -Acetyltransferase | en_US |
dc.subject.other | Human Genetics | en_US |
dc.title | Characterization of human lymphocyte N -acetyltransferase and its relationship to the isoniazid acetylator polymorphism | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Pharmacology, University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Pharmacology, University of Michigan, 48109, Ann Arbor, Michigan; Division of Pathology and Toxicology, Naylor Dana Institute for Disease Prevention, American Health Foundation, 10595, Valhalla, New York | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7225085 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44137/1/10528_2004_Article_BF00500122.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00500122 | en_US |
dc.identifier.source | Biochemical Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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