Transcript identification in the BRCA1 candidate region
dc.contributor.author | Abel, Kenneth J. | en_US |
dc.contributor.author | Couch, Fergus J. | en_US |
dc.contributor.author | Merajver, Sofia D. | en_US |
dc.contributor.author | Castilla, Lucio H. | en_US |
dc.contributor.author | Brody, Lawrence C. | en_US |
dc.contributor.author | Collins, Francis S. | en_US |
dc.contributor.author | Weber, Barbara L. | en_US |
dc.date.accessioned | 2006-09-11T14:25:53Z | |
dc.date.available | 2006-09-11T14:25:53Z | |
dc.date.issued | 1995-02 | en_US |
dc.identifier.citation | Weber, Barbara L.; Abel, Kenneth J.; Couch, Fergus J.; Merajver, Sofia; Castilla, Lucio; Brody, Lawrence C.; Collins, Francis S.; (1995). "Transcript identification in the BRCA1 candidate region." Breast Cancer Research and Treatment 33(2): 115-124. <http://hdl.handle.net/2027.42/44201> | en_US |
dc.identifier.issn | 1573-7217 | en_US |
dc.identifier.issn | 0167-6806 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44201 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7749139&dopt=citation | en_US |
dc.description.abstract | Chromosome 17q12-21 is known to contain a gene (or genes) which confers susceptibility to early-onset breast cancer and ovarian cancer (BRCA1). Identification and isolation of BRCA1 will likely provide the basis for increased understanding of the pathogenesis of breast and ovarian cancer, the development of targeted diagnostic and therapeutic approaches, and a means of screening women at risk of being BRCA1 mutation carriers. Genetic and physical maps of the BRCA1 candidate region have been largely completed and efforts are being directed at identification of candidate genes from within this region. We have begun the task of identifying transcripts from this region employing three complementary strategies. These include: 1) direct cDNA screening with cosmids derived from the BRCA1 region; 2) exon amplification; and 3) magnetic bead capture. Transcripts identified using these approaches are being characterized for: 1) tissue expression pattern; 2) the presence of genomic rearrangement in DNA derived from affected members of families believed to show linkage between breast cancer and genetic markers in the BRCA1 candidate interval; 3) altered size and/or expression pattern in RNA prepared from such individuals; and 4) homology to known genes or functional motifs. Germline mutations in affected individuals from these families will serve as presumptive evidence of BRCA1 identity. | en_US |
dc.format.extent | 818330 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Breast/Ovarian Cancer Susceptibility Gene | en_US |
dc.subject.other | CDNA | en_US |
dc.subject.other | Exon Amplification | en_US |
dc.subject.other | Molecular Cloning | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | BRCA1 | en_US |
dc.subject.other | Tumor Suppressor Gene | en_US |
dc.title | Transcript identification in the BRCA1 candidate region | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Ophthalmology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Medicine, University of Pennsylvania, Room 1009 BRB I, 422 Curie Blvd., 19104, Philadelphia, PA, USA | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Biology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | National Center for Human Genome Research, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | National Center for Human Genome Research, Bethesda, MD, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7749139 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44201/1/10549_2004_Article_BF00682719.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00682719 | en_US |
dc.identifier.source | Breast Cancer Research and Treatment | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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