2. Survival Impact of HER-2/Neu, Cox-2, Urokinase Plasminogen Activator (upa), Cytokeratin 17/5,6 and other Markers with Long-Term Outcome of Early Breast Cancer. Report from the British Columbia Tissue Micro-Array Project (BCTMAP)
dc.contributor.author | Ragaz, J. | en_US |
dc.contributor.author | Van Rijn, M. | en_US |
dc.contributor.author | Brodie, A. | en_US |
dc.contributor.author | Jelovac, Danijela | en_US |
dc.contributor.author | Nielsen, T. | en_US |
dc.contributor.author | Dedhar, S. | en_US |
dc.contributor.author | Huntsman, D. | en_US |
dc.contributor.author | Hayes, M. | en_US |
dc.contributor.author | Dunn, S. | en_US |
dc.contributor.author | Cheung, M. | en_US |
dc.contributor.author | Sledge, George W. | en_US |
dc.contributor.author | Chia, S. | en_US |
dc.contributor.author | Harris, Adrian | en_US |
dc.contributor.author | Bajdik, C. | en_US |
dc.contributor.author | Speers, C. | en_US |
dc.contributor.author | Spinelli, J. | en_US |
dc.contributor.author | Hayes, Daniel F. | en_US |
dc.contributor.author | Lippman, Marc E. | en_US |
dc.date.accessioned | 2006-09-11T14:27:07Z | |
dc.date.available | 2006-09-11T14:27:07Z | |
dc.date.issued | 2003-05 | en_US |
dc.identifier.citation | Ragaz, J.; Lippman, M.; Van Rijn, M.; Brodie, A.; Jelovac, Danijela; Nielsen, T.; Dedhar, S.; Huntsman, D.; Hayes, M.; Dunn, S.; Cheung, M.; Sledge, G.; Chia, S.; Harris, A.; Bajdik, C.; Speers, C.; Spinelli, J.; Hayes, D.; (2003). "2. Survival Impact of HER-2/Neu, Cox-2, Urokinase Plasminogen Activator (upa), Cytokeratin 17/5,6 and other Markers with Long-Term Outcome of Early Breast Cancer. Report from the British Columbia Tissue Micro-Array Project (BCTMAP) ." Breast Cancer Research and Treatment 79(2): 278-278. <http://hdl.handle.net/2027.42/44215> | en_US |
dc.identifier.issn | 0167-6806 | en_US |
dc.identifier.issn | 1573-7217 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44215 | |
dc.description.abstract | Tumor samples are available from over 19,600 Stage I-III breast cancer patients treated according to evolving British Columbia guidelines from 1978 to 1990. A tissue mico-array (TMA) was constructed from 930 of these patients, all of whom participated in randomized or phase II studies. Outcome was defined as 20-year Breast Cancer specific Survival (BrCaSS), with events defined as Breast Ca death. Follow up was median 17.8 years (ranges 11–28). Multiple tumor markers were tested, and results correlated with 20-year BrCaSS for markers expressed versus non-expressed. No difference in BrCaSS was found for aromatase, integrin-linked kinase (ILK), IGF-1 and Topo-isomerase-2. The negative predictive value of IHC versus FISH and ACIS-IHC versus FISH was 96 and 97%, respectively. The positive predictive value of IHC versus FISH and ACIS-IHC versus FISH was 84 and 84%, respectively. All tests, with the exception of HER-2 FISH were done by IHC. Results of other markers (VEGF, ER/PgR, hypoxia markers, etc.), and an interactive multivariate analysis adjusting for conventional prognostic factors and for all above markers, are in progress. | en_US |
dc.format.extent | 30922 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.title | 2. Survival Impact of HER-2/Neu, Cox-2, Urokinase Plasminogen Activator (upa), Cytokeratin 17/5,6 and other Markers with Long-Term Outcome of Early Breast Cancer. Report from the British Columbia Tissue Micro-Array Project (BCTMAP) | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Ophthalmology | en_US |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | Stanford University, Stanford, CA, USA | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of Maryland, Baltimore, MD, USA | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of Indiana, Indianapolois, IN, USA | en_US |
dc.contributor.affiliationother | University of Oxford, UK | en_US |
dc.contributor.affiliationother | University of British Columbia, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of Maryland, Baltimore, MD, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44215/1/10549_2004_Article_5127209.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1023979226714 | en_US |
dc.identifier.source | Breast Cancer Research and Treatment | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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