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Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
dc.contributor.authorAhn, Jiyoungen_US
dc.contributor.authorNowell, Susan A.en_US
dc.contributor.authorRae, James Michaelen_US
dc.contributor.authorScheys, Joshua O.en_US
dc.contributor.authorTrovato, Andrewen_US
dc.contributor.authorSweeney, Carolen_US
dc.contributor.authorMacLeod, Stewart L.en_US
dc.contributor.authorKadlubar, Fred F.en_US
dc.contributor.authorAmbrosone, Christine B.en_US
dc.date.accessioned2006-09-11T14:28:08Z
dc.date.available2006-09-11T14:28:08Z
dc.date.issued2005-06en_US
dc.identifier.citationNowell, Susan A.; Ahn, Jiyoung; Rae, James M.; Scheys, Joshua O.; Trovato, Andrew; Sweeney, Carol; MacLeod, Stewart L.; Kadlubar, Fred F.; Ambrosone, Christine B.; (2005). "Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients." Breast Cancer Research and Treatment 91(3): 249-258. <http://hdl.handle.net/2027.42/44227>en_US
dc.identifier.issn0167-6806en_US
dc.identifier.issn1573-7217en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44227
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15952058&dopt=citationen_US
dc.description.abstractTamoxifen has been a mainstay of adjuvant therapy for breast cancer for many years. We sought to determine if genetic variability in the tamoxifen metabolic pathway influenced overall survival in breast cancer patients treated with tamoxifen. We examined functional polymorphisms in CYP2D6, the P450 catalyzing the formation of active tamoxifen metabolites, and UGT2B15, a Phase II enzyme facilitating the elimination of active metabolite in a retrospective study of breast cancer patients. We also examined whether the combination of variant alleles in SULT1A1 and UGT2B15 had more of an impact on overall survival in tamoxifen-treated patients than when the genes were examined separately.en_US
dc.format.extent267859 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers; Springeren_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherGenetic Variationen_US
dc.subject.otherOncologyen_US
dc.subject.otherBreast Canceren_US
dc.subject.otherCYP2D6en_US
dc.subject.otherSULT1A1en_US
dc.subject.otherTamoxifenen_US
dc.subject.otherUGT2B15en_US
dc.titleAssociation of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patientsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelOtolaryngologyen_US
dc.subject.hlbsecondlevelObstetrics and Gynecologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbsecondlevelOphthalmologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan School of Medicine, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan School of Medicine, USAen_US
dc.contributor.affiliationotherDepartment of Epidemiology, Roswell Park Cancer Institute, BSB Room S701, Elm & Carlton Streets, Buffalo, NY, 14263, USAen_US
dc.contributor.affiliationotherMerck and Company, Rahway, NJ, USAen_US
dc.contributor.affiliationotherDepartment of Epidemiology, Roswell Park Cancer Institute, BSB Room S701, Elm & Carlton Streets, Buffalo, NY, 14263, USAen_US
dc.contributor.affiliationotherDepartment of Epidemiology, Roswell Park Cancer Institute, BSB Room S701, Elm & Carlton Streets, Buffalo, NY, 14263, USAen_US
dc.contributor.affiliationotherDepartment of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USAen_US
dc.contributor.affiliationotherUniversity of Arkansas for Medical Sciences, USAen_US
dc.contributor.affiliationotherDivision of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid15952058en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44227/1/10549_2004_Article_7751.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s10549-004-7751-xen_US
dc.identifier.sourceBreast Cancer Research and Treatmenten_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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