RhoC-GTPase is a Novel Tissue Biomarker Associated with Biologically Aggressive Carcinomas of the Breast
dc.contributor.author | Sabel, Michael S. | en_US |
dc.contributor.author | Merajver, Sofia D. | en_US |
dc.contributor.author | Kleer, Celina G. | en_US |
dc.contributor.author | Griffith, Kent A. | en_US |
dc.contributor.author | Gallagher, Gary | en_US |
dc.contributor.author | Wu, Zhi-Fen | en_US |
dc.contributor.author | Golen, Kenneth L. | en_US |
dc.date.accessioned | 2006-09-11T14:28:29Z | |
dc.date.available | 2006-09-11T14:28:29Z | |
dc.date.issued | 2005-09 | en_US |
dc.identifier.citation | Kleer, Celina G.; Griffith, Kent A.; Sabel, Michael S.; Gallagher, Gary; Golen, Kenneth L.; Wu, Zhi-Fen; Merajver, Sofia D.; (2005). "RhoC-GTPase is a Novel Tissue Biomarker Associated with Biologically Aggressive Carcinomas of the Breast." Breast Cancer Research and Treatment 93(2): 101-110. <http://hdl.handle.net/2027.42/44231> | en_US |
dc.identifier.issn | 0167-6806 | en_US |
dc.identifier.issn | 1573-7217 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44231 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16187229&dopt=citation | en_US |
dc.description.abstract | Background. There is a need for reliable predictors of breast cancer aggressiveness that will further refine the staging classification and help guide the implementation of novel therapies. We have identified RhoC as being nearly always overexpressed in the most aggressive form of breast cancer, inflammatory breast cancer (IBC); in subsequent work we identified RhoC to be a promising marker of aggressive behavior in breast cancers less than 1 cm in diameter. We hypothesized that RhoC expression would identify aggressive, non-IBC tumors breast cancer patients at any stage with worse outcomes defined as recurrence and/or metastasis. | en_US |
dc.format.extent | 369517 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.title | RhoC-GTPase is a Novel Tissue Biomarker Associated with Biologically Aggressive Carcinomas of the Breast | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Ophthalmology | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology and Internal Medicine, University of Michigan, Ann Arbour, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbour, MI, USA; 2G332 University Hospital, 1500 E. Medical Center Dr., Ann Arbour, MI, 48109-0054, USA | en_US |
dc.contributor.affiliationum | Department of Biostatistics and Internal Medicine, University of Michigan, Ann Arbour, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbour, MI, USA | en_US |
dc.contributor.affiliationum | Department of Surgery and Internal Medicine, University of Michigan, Ann Arbour, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbour, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology and Internal Medicine, University of Michigan, Ann Arbour, MI, USA | en_US |
dc.contributor.affiliationum | Division of Hematology/Oncology, University of Michigan, Ann Arbour, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbour, MI, USA | en_US |
dc.contributor.affiliationum | Division of Hematology/Oncology, University of Michigan, Ann Arbour, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbour, MI, USA | en_US |
dc.contributor.affiliationum | Division of Hematology/Oncology, University of Michigan, Ann Arbour, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbour, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 16187229 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44231/1/10549_2005_Article_4170.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s10549-005-4170-6 | en_US |
dc.identifier.source | Breast Cancer Research and Treatment | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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