Effect of bile and fat on gastric motility under the influence of various stimulants

Abstract

This study was initiated to evaluate the effect on contractility of the longitudinal and circular muscles of the canine gastric body and antrum when micellar fat or bile was instilled in a Thiry loop of duodenum. These studies were performed while the animals were stimulated by food, acetylcholine, and 5-hydroxytryptophane (5-HTP). The latter two chemicals were infused for a 30-min. period. Micellar fat in the duodenum tended to decrease the frequency and amplitude of contractions only in those experiments using 5-HTP or the lower dose of acetylcholine (50 µg./kg./min.) as stimulants. This trend was not seen when bile alone or saline was placed in the duodenal loop. The data were evaluated by a motility index technic and analyzed by a paired comparison method.