Intraepithelial leukocytes of the intestinal mucosa in normal man and in Whipple's disease
dc.contributor.author | Austin, Linda Lee | en_US |
dc.contributor.author | Dobbins, William O. III | en_US |
dc.date.accessioned | 2006-09-11T14:44:01Z | |
dc.date.available | 2006-09-11T14:44:01Z | |
dc.date.issued | 1982-04 | en_US |
dc.identifier.citation | Austin, Linda Lee; Dobbins, William O.; (1982). "Intraepithelial leukocytes of the intestinal mucosa in normal man and in Whipple's disease." Digestive Diseases and Sciences 27(4): 311-320. <http://hdl.handle.net/2027.42/44392> | en_US |
dc.identifier.issn | 0163-2116 | en_US |
dc.identifier.issn | 1573-2568 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44392 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6175489&dopt=citation | en_US |
dc.description.abstract | Intraepithelial lymphocytes (IEL) of the intestinal mucosa of normal man and of patients with Whipple's disease were studied by light microscopy of 1-μm-thick sections, and by electron microscopy of thin sections. IEL in normal human intestine tend to be elongated in outline, have few cytoplasmic organelles, have compact nuclei, and are unattached to epithelial cells. IEL in Whipple's disease are more likely to be activated in appearance, ie, to be larger and to contain more cytoplasmic organelles than IEL of normal intestine. The number of IEL/100 intestinal epithelial cells is similar in normal man and in patients with Whipple's disease. Other intraepithelial (IE) cells found in normal intestine include eosinophils and mast cells, and we note for the first time the presence of IE macrophages. There are no “globule leukocytes” in the intestine of normal man or of patients with Whipple's disease. Other IE cells found in the intestine in Whipple's disease include eosinophils, polymorphonuclear (PMN) leukocytes, and macrophages in untreated disease and intraepithelial macrophages in treated disease. These IE cells may be involved in the acute and chronic immune responses of the intestine. | en_US |
dc.format.extent | 2944309 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Digestive Disease Systems, Inc. ; Springer Science+Business Media | en_US |
dc.subject.other | Hepatology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Gastroenterology | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Transplant Surgery | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.title | Intraepithelial leukocytes of the intestinal mucosa in normal man and in Whipple's disease | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center, 2215 Fuller Road, 48105, Ann Arbor, Michigan; Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical Center, USA | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center, 2215 Fuller Road, 48105, Ann Arbor, Michigan; Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical Center, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6175489 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44392/1/10620_2005_Article_BF01296750.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01296750 | en_US |
dc.identifier.source | Digestive Diseases and Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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