Increased thymic hormone responsive suppressor T lymphocyte function in chronic active hepatitis
dc.contributor.author | Mutchnick, Milton G. | en_US |
dc.contributor.author | Schaffner, John A. | en_US |
dc.contributor.author | Prieto, Jorge A. | en_US |
dc.contributor.author | Weller, Frederick E. | en_US |
dc.contributor.author | Goldstein, Allan L. | en_US |
dc.date.accessioned | 2006-09-11T14:44:14Z | |
dc.date.available | 2006-09-11T14:44:14Z | |
dc.date.issued | 1983-04 | en_US |
dc.identifier.citation | Mutchnick, Milton G.; Schaffner, John A.; Prieto, Jorge A.; Weller, Frederick E.; Goldstein, Allan L.; (1983). "Increased thymic hormone responsive suppressor T lymphocyte function in chronic active hepatitis." Digestive Diseases and Sciences 28(4): 328-334. <http://hdl.handle.net/2027.42/44394> | en_US |
dc.identifier.issn | 0163-2116 | en_US |
dc.identifier.issn | 1573-2568 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44394 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6219866&dopt=citation | en_US |
dc.description.abstract | Mitogen-induced suppressor T lymphocyte function was evaluated in patients with chronic active hepatitis (CAH). The in vitro effect of the biological response modifier, thymosin fraction 5, on the suppressive activity of peripheral blood mononuclear cells (PBM) was also assessed. Suppressor cell activity was significantly decreased in patients with CAH when compared to controls ( P <0.001). In the absence of the inducing mitogen, thymosin-treated PBM from both patients and controls promoted enhancement of tritiated thymidine uptake by cocultured allogeneic lymphocytes. When thymosin-treated mononuclear cells were mitogen-activated; patients, but not the controls, showed a marked increase in suppressor activity ( P <0.001). These results indicate that the polypeptides contained in thymosin fraction 5 can promote a helper effect in patients and controls. Furthermore, PBM from patients with CAH contain a subset of lymphocytes that can express a suppressive function following thymosin treatment. We conclude that thymosin fraction 5 can promote an in vitro restoration of suppressor T cell function in patients with CAH. | en_US |
dc.format.extent | 686173 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Digestive Disease Systems, Inc. ; Springer Science+Business Media | en_US |
dc.subject.other | Hepatology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Gastroenterology | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Transplant Surgery | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.title | Increased thymic hormone responsive suppressor T lymphocyte function in chronic active hepatitis | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan; Department of Medicine, Ann Arbor V.A. Medical Center, 2215 Fuller Road, 48105, Ann Arbor, Michigan; Department of Biochemistry, The George Washington University School of Medicine and Health Sciences, Washington, DC | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan; Department of Medicine, Ann Arbor V.A. Medical Center, 2215 Fuller Road, 48105, Ann Arbor, Michigan; Department of Biochemistry, The George Washington University School of Medicine and Health Sciences, Washington, DC | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan; Department of Medicine, Ann Arbor V.A. Medical Center, 2215 Fuller Road, 48105, Ann Arbor, Michigan; Department of Biochemistry, The George Washington University School of Medicine and Health Sciences, Washington, DC | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan; Department of Medicine, Ann Arbor V.A. Medical Center, 2215 Fuller Road, 48105, Ann Arbor, Michigan; Department of Biochemistry, The George Washington University School of Medicine and Health Sciences, Washington, DC | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan; Department of Medicine, Ann Arbor V.A. Medical Center, 2215 Fuller Road, 48105, Ann Arbor, Michigan; Department of Biochemistry, The George Washington University School of Medicine and Health Sciences, Washington, DC | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6219866 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44394/1/10620_2005_Article_BF01324949.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01324949 | en_US |
dc.identifier.source | Digestive Diseases and Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.