Correlation between serum HCV RNA and aminotransferase levels in patients with chronic HCV infection
dc.contributor.author | Chan, T. M. | en_US |
dc.contributor.author | Ghany, Marc G. | en_US |
dc.contributor.author | Sanchez-Pescador, R. | en_US |
dc.contributor.author | Lok, Anna Suk-Fong | en_US |
dc.contributor.author | Urdea, M. | en_US |
dc.date.accessioned | 2006-09-11T14:46:53Z | |
dc.date.available | 2006-09-11T14:46:53Z | |
dc.date.issued | 1996-11 | en_US |
dc.identifier.citation | Ghany, M. G.; Chan, T. M.; Sanchez-Pescador, R.; Urdea, M.; Lok, A. S. F.; (1996). "Correlation between serum HCV RNA and aminotransferase levels in patients with chronic HCV infection." Digestive Diseases and Sciences 41(11): 2213-2218. <http://hdl.handle.net/2027.42/44425> | en_US |
dc.identifier.issn | 0163-2116 | en_US |
dc.identifier.issn | 1573-2568 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44425 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8943974&dopt=citation | en_US |
dc.description.abstract | Cross-sectional studies on the correlation between serum hepatitis C virus (HCV) RNA and alanine aminotransferase (ALT) levels in patients with chronic hepatitis C have yielded conflicting results. We conducted a longitudinal study to examine the correlation between HCV viremia and serum ALT levels in individual patients over time. Serial samples (mean 9) from 25 patients with chronic HCV infection, including interferon-treated and untreated immunocompetent and immunosuppressed patients, collected over a period of 1–4.8 years (mean 2.6 years) were tested for HCV RNA and ALT levels using a highly reproducible quantitative (bDNA) assay. A significant correlation was found between serum HCV RNA and ALT levels in the patients who received IFN therapy, but no correlation was observed in the untreated patients. Among the untreated patients, the immunosuppressed patients had significantly higher HCV RNA levels (39±4 vs 3.6±8 Meq/ml, P <0.0001) but significantly lower ALT (56±11 vs 97±12 units/liter, P =0.03) levels when compared to the immunocompetent ones. In summary, we found no correlation between serum HCV RNA and ALT levels in chronic hepatitis C patients who are not receiving interferon therapy. Immunosuppression results in higher HCV RNA but lower ALT levels. | en_US |
dc.format.extent | 579451 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Immunosuppressive Therapy | en_US |
dc.subject.other | Transplant Surgery | en_US |
dc.subject.other | Hepatology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Gastroenterology | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Renal Transplantation | en_US |
dc.subject.other | Chronic Hepatitis C | en_US |
dc.subject.other | Interferon | en_US |
dc.title | Correlation between serum HCV RNA and aminotransferase levels in patients with chronic HCV infection | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | From the Section of Gastroenterology and Hepatology, Tulane University Medical Center, New Orleans, Louisiana; Department of Medicine, University of Hong Kong, Hong Kong; Chiron Corporation, Emeryville, California; Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, 1500 East Medical Center Drive, Box 0362, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | From the Section of Gastroenterology and Hepatology, Tulane University Medical Center, New Orleans, Louisiana; Department of Medicine, University of Hong Kong, Hong Kong; Chiron Corporation, Emeryville, California | en_US |
dc.contributor.affiliationother | From the Section of Gastroenterology and Hepatology, Tulane University Medical Center, New Orleans, Louisiana; Department of Medicine, University of Hong Kong, Hong Kong; Chiron Corporation, Emeryville, California | en_US |
dc.contributor.affiliationother | From the Section of Gastroenterology and Hepatology, Tulane University Medical Center, New Orleans, Louisiana; Department of Medicine, University of Hong Kong, Hong Kong; Chiron Corporation, Emeryville, California | en_US |
dc.contributor.affiliationother | From the Section of Gastroenterology and Hepatology, Tulane University Medical Center, New Orleans, Louisiana; Department of Medicine, University of Hong Kong, Hong Kong; Chiron Corporation, Emeryville, California | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8943974 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44425/1/10620_2005_Article_BF02071402.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02071402 | en_US |
dc.identifier.source | Digestive Diseases and Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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