Total Parenteral Nutrition-Associated Changes in Mouse Intestinal Intraepithelial Lymphocytes
dc.contributor.author | Teitelbaum, Daniel H. | en_US |
dc.contributor.author | Mosley, R. Lee | en_US |
dc.contributor.author | Yang, Hua | en_US |
dc.contributor.author | Forbush, Benjamin | en_US |
dc.contributor.author | Antony, Paul | en_US |
dc.contributor.author | Kiristioglu, Irfan | en_US |
dc.contributor.author | Fan, Yongyi | en_US |
dc.date.accessioned | 2006-09-11T14:47:19Z | |
dc.date.available | 2006-09-11T14:47:19Z | |
dc.date.issued | 2002-05 | en_US |
dc.identifier.citation | Kiristioglu, Irfan; Antony, Paul; Fan, Yongyi; Forbush, Benjamin; Mosley, R. Lee; Yang, Hua; Teitelbaum, Daniel H.; (2002). "Total Parenteral Nutrition-Associated Changes in Mouse Intestinal Intraepithelial Lymphocytes." Digestive Diseases and Sciences 47(5): 1147-1157. <http://hdl.handle.net/2027.42/44430> | en_US |
dc.identifier.issn | 1573-2568 | en_US |
dc.identifier.issn | 0163-2116 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44430 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12018915&dopt=citation | en_US |
dc.description.abstract | Intraepithelial lymphocytes (IEL) play a major role in mucosal defense mechanisms against intraluminal foreign antigens. To address the role luminal nutrients have on the phenotype and function of the IEL, we administered total parenteral nutrition (TPN) to mice, with the absence of enteral intake. We hypothesized that administration of TPN would result in changes in the phenotype and function of the IEL. For this, we utilized a mouse model of TPN. A significant decline in the CD4 + IEL population occurred with TPN. Additionally, the CD8 + ,CD44 + IEL subset showed a 65% decline (P < 0.05) , and the CD4 + ,CD44 + subset declined by 55% with TPN (P < 0.05) . The CD8αβ + population (a marker of thymic-dependence) also declined by 92% (P < 0.01) with TPN. IEL in the TPN group showed a significantly lower degree of in vitro proliferation. In conclusion, the IEL showed significant phenotypic changes with TPN including the loss of the thymic-derived population. Functionally, the IEL showed a significant decline in proliferation. Such changes demonstrate the important role luminal nutrients have on IEL phenotype and function. | en_US |
dc.format.extent | 184452 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Gastroenterology | en_US |
dc.subject.other | CD8 | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Hepatology | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Transplant Surgery | en_US |
dc.subject.other | Intraepithelial Lymphocytes | en_US |
dc.subject.other | Total Parenteral Nutrition | en_US |
dc.subject.other | CD4 | en_US |
dc.subject.other | CD8αβ | en_US |
dc.subject.other | CD44 | en_US |
dc.subject.other | CD62L | en_US |
dc.title | Total Parenteral Nutrition-Associated Changes in Mouse Intestinal Intraepithelial Lymphocytes | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, and C. S. Mott Children's Hospital, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, and C. S. Mott Children's Hospital, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, and C. S. Mott Children's Hospital, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, and C. S. Mott Children's Hospital, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, and C. S. Mott Children's Hospital, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, and C. S. Mott Children's Hospital, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, and C. S. Mott Children's Hospital, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 12018915 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44430/1/10620_2004_Article_373218.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015066813675 | en_US |
dc.identifier.source | Digestive Diseases and Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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