Acute Liver Failure Due To Amoxicillin and Amoxicillin/Clavulanate
dc.contributor.author | Fontana, Robert John | en_US |
dc.contributor.author | Shakil, A. Obaid | en_US |
dc.contributor.author | Greenson, Joel K. | en_US |
dc.contributor.author | Boyd, Ian | en_US |
dc.contributor.author | Lee, William M. | en_US |
dc.date.accessioned | 2006-09-11T14:47:52Z | |
dc.date.available | 2006-09-11T14:47:52Z | |
dc.date.issued | 2005-10 | en_US |
dc.identifier.citation | Fontana, Robert J.; Shakil, A. Obaid; Greenson, Joel K.; Boyd, Ian; Lee, William M.; (2005). "Acute Liver Failure Due To Amoxicillin and Amoxicillin/Clavulanate." Digestive Diseases and Sciences 50(10): 1785-1790. <http://hdl.handle.net/2027.42/44436> | en_US |
dc.identifier.issn | 0163-2116 | en_US |
dc.identifier.issn | 1573-2568 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44436 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16187174&dopt=citation | en_US |
dc.description.abstract | The aim of our study is to report upon the presentation of two patients with life-threatening acute liver failure (ALF) due to amoxicillin and amoxicillin/clavulanate. A 59-year-old, Caucasian male presented with ALF 34 days after receiving amoxicillin/clavulanate. Despite aggressive supportive care, he died on hospital day 10. A 42-year-old, Caucasian female presented with ALF 21 days after receiving amoxicillin. She underwent successful liver transplantation on hospital day 19. In both cases, all competing causes of ALF had been excluded, liver pathology was consistent with drug-induced hepatitis, and cases were deemed “definite/highly probable” using causality assessment. Amongst 14 prior ALF/death cases due to amoxicillin/clavulanate, the mean age (62 years), male predominance (57%), and mean delay from drug cessation to presentation (17 days) is similar to what has been reported in patients with self-limited cholestatic hepatitis. Acute liver failure is a rare manifestation of amoxicillin and amoxicillin/clavulanate hepatotoxicity with no obvious clinical features at presentation portending a poor prognosis. Early transfer of patients with severe drug-induced hepatotoxicity (i.e., encephalopathy or coagulopathy) to a transplant center is recommended due to their poor likelihood of recovery. | en_US |
dc.format.extent | 266259 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Springer Science + Business Media, Inc. | en_US |
dc.subject.other | Gastroenterology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Acute Liver Failure | en_US |
dc.subject.other | Hepatotoxicity | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Hepatology | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Transplant Surgery | en_US |
dc.subject.other | Amoxicillin/Clavulanate | en_US |
dc.subject.other | Transplantation | en_US |
dc.title | Acute Liver Failure Due To Amoxicillin and Amoxicillin/Clavulanate | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA; 3912 Taubman Center, Ann Arbor, Michigan, 48109-0362, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Texas Southwestern, Dallas, Texas, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania | en_US |
dc.contributor.affiliationother | Adverse Drug Reactions Unit, Therapeutic Goods Administration, Canberra, Australia | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 16187174 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44436/1/10620_2005_Article_2938.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s10620-005-2938-5 | en_US |
dc.identifier.source | Digestive Diseases and Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.