A Theoretical Model of a Molecular-Motor-Powered Pump
dc.contributor.author | Bull, Joseph L. | en_US |
dc.contributor.author | Hunt, Alan J. | en_US |
dc.contributor.author | Meyhöfer, Edgar | en_US |
dc.date.accessioned | 2006-09-11T14:51:31Z | |
dc.date.available | 2006-09-11T14:51:31Z | |
dc.date.issued | 2005-03 | en_US |
dc.identifier.citation | Bull, Joseph L.; Hunt, Alan J.; Meyhöfer, Edgar; (2005). "A Theoretical Model of a Molecular-Motor-Powered Pump." Biomedical Microdevices 7(1): 21-33. <http://hdl.handle.net/2027.42/44478> | en_US |
dc.identifier.issn | 1387-2176 | en_US |
dc.identifier.issn | 1572-8781 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44478 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15834517&dopt=citation | en_US |
dc.description.abstract | The motion of a cylindrical bead in a fluid contained within a two-dimensional channel is investigated using the boundary element method as a model of a biomolecular-motor-powered microfluidics pump. The novelty of the pump lies in the use of motor proteins (kinesin) to power the bead motion and the few moving parts comprising the pump. The performance and feasibility of this pump design is investigated using two model geometries: a straight channel, and a curved channel with two concentric circular walls. In the straight channel geometry, it is shown that increasing the bead radius relative to the channel width, increases the flow rate at the expense of increasing the force the kinesins must generate in order to move the bead. Pump efficiency is generally higher for larger bead radii, and larger beads can support higher imposed loads. In the circular channel geometry, it is shown that bead rotation modifies the force required to move the bead and that shifting the bead inward slightly reduces the required force. Bead rotation has a minimal effect on flow rate. Recirculation regions, which can develop between the bead and the channel walls, influence the stresses and force on the bead. These results suggest this pump design is feasible, and the kinesin molecules provide sufficient force to deliver pico- to atto- l/s flows. | en_US |
dc.format.extent | 2798815 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science + Business Media, Inc. | en_US |
dc.subject.other | Engineering | en_US |
dc.subject.other | Nanotechnology | en_US |
dc.subject.other | Biophysics/Biomedical Physics | en_US |
dc.subject.other | Engineering Fluid Dynamics | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Microfluidics | en_US |
dc.subject.other | Kinesin | en_US |
dc.subject.other | Stokes Flow | en_US |
dc.subject.other | Boundary Element Method | en_US |
dc.title | A Theoretical Model of a Molecular-Motor-Powered Pump | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI, 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI, 48109, USA | en_US |
dc.contributor.affiliationum | Department of Mechanical Engineering, The University of Michigan, Ann Arbor, MI, 48109, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15834517 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44478/1/10544_2005_Article_6168.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s10544-005-6168-6 | en_US |
dc.identifier.source | Biomedical Microdevices | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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