Themotaxis of metastatic tumor cells
dc.contributor.author | Varani, James | en_US |
dc.date.accessioned | 2006-09-11T14:53:17Z | |
dc.date.available | 2006-09-11T14:53:17Z | |
dc.date.issued | 1982-03 | en_US |
dc.identifier.citation | Varani, James; (1982). "Themotaxis of metastatic tumor cells." Cancer and Metastasis Review 1(1): 17-28. <http://hdl.handle.net/2027.42/44492> | en_US |
dc.identifier.issn | 0167-7659 | en_US |
dc.identifier.issn | 1573-7233 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44492 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7185418&dopt=citation | en_US |
dc.description.abstract | A number of factors have been identified which are chemotactic for tumor cells. Recent studies have shown that, in addition to inducing directional motility in the Boyden chamber assay, these factors also induce a number of other responses. Included among these responses are cell swelling and foreign surface adhesiveness. The adherence response has been studied in detail using the Walker 256 carcinosarcoma cells and several other cell types. In the Walker cells, treatment with the C5a-derived tumor cell chemotactic peptide, the synthetic tripeptide, N-formyl-methionyl-leucyl-phenylalanine or with 12-O-tetradecanoyl phorbol ester induces a rapid, transient adherence response. The response is completely inhibited by several agents known to block the activity of phospholipase A 2 or the metabolism of arachidonic acid through the lipoxygenase pathway but is not inhibited by inhibition of the cychlooxygenase pathway. This suggests that lipoxygenase metabolites of arachidonic acid may actually mediate the adherence response. | en_US |
dc.format.extent | 1123861 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Martinus Nijhoff, The Hague/Kluwer Academic Publishers; Martinus Nijhoff Publishers ; Springer Science+Business Media | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Cancer Research | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Tumor Cells | en_US |
dc.subject.other | Chemotactic Factors | en_US |
dc.subject.other | Adherence | en_US |
dc.subject.other | Metastasis | en_US |
dc.title | Themotaxis of metastatic tumor cells | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Medical School, 48109, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7185418 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44492/1/10555_2004_Article_BF00049478.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00049478 | en_US |
dc.identifier.source | Cancer and Metastasis Review | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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