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Comparative effect of C3a and C5a on adhesion molecule expression on neutrophils and endothelial cells
dc.contributor.authorForeman, K. E.en_US
dc.contributor.authorGlovsky, M. M.en_US
dc.contributor.authorWarner, Roscoe L.en_US
dc.contributor.authorHorvath, S. J.en_US
dc.contributor.authorWard, Peter A.en_US
dc.date.accessioned2006-09-11T14:55:04Z
dc.date.available2006-09-11T14:55:04Z
dc.date.issued1996-02en_US
dc.identifier.citationForeman, K. E.; Glovsky, M. M.; Warner, R. L.; Horvath, S. J.; Ward, P. A.; (1996). "Comparative effect of C3a and C5a on adhesion molecule expression on neutrophils and endothelial cells." Inflammation 20(1): 1-9. <http://hdl.handle.net/2027.42/44514>en_US
dc.identifier.issn0360-3997en_US
dc.identifier.issn1573-2576en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44514
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8926043&dopt=citationen_US
dc.description.abstractComplement activation is known to enhance neutrophil binding to human umbilical vein endothelial cells (HUVECs). Recently, we have shown that recombinant human C5a upregulates P-selectin in HUVECs. Unstimulated human neutrophil binding is also increased on C5a stimulated HUVECs. We demonstrate in this report that C5a upregulates CD11b/CD18 in human neutrophils. Also shown is that synthetic C3a 57–77 and an analog 15 amino acid C3a peptide (C3a 15 ) neither upregulate CD11b/CD18 nor do the C3a peptides increase P-selectin, ICAM-1 or E-selectin in HUVECs. Thus C5a and not C3a is responsible for early (∼30 minutes) neutrophil adhesion to endothelial cells after complement activation.en_US
dc.format.extent441106 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherInternal Medicineen_US
dc.subject.otherPathologyen_US
dc.subject.otherRheumatologyen_US
dc.titleComparative effect of C3a and C5a on adhesion molecule expression on neutrophils and endothelial cellsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPathologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, Michigan; Parke-Davis Research Division of Warner-Lambert Company, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherCaltech Beckman Institute, Pasadena, Californiaen_US
dc.contributor.affiliationotherAsthma and Allergy Center, Huntington Memorial Hospital, Pasadena, Californiaen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid8926043en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44514/1/10753_2005_Article_BF01487740.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF01487740en_US
dc.identifier.sourceInflammationen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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