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Role of Chemotactic Factors in Neutrophil Activation After Thermal Injury in Rats

dc.contributor.authorPiccolo, Maria-Thereza S.en_US
dc.contributor.authorWang, Yunen_US
dc.contributor.authorVerbrugge, Sergeen_US
dc.contributor.authorWarner, Roscoe L.en_US
dc.contributor.authorSannomiya, Paulinaen_US
dc.contributor.authorPiccolo, Nelson S.en_US
dc.contributor.authorPiccolo, Monica S.en_US
dc.contributor.authorHugli, Tony E.en_US
dc.contributor.authorWard, Peter A.en_US
dc.contributor.authorTill, Gerd O.en_US
dc.date.accessioned2006-09-11T14:56:01Z
dc.date.available2006-09-11T14:56:01Z
dc.date.issued1999-08en_US
dc.identifier.citationPiccolo, Maria-Thereza S.; Wang, Yun; Verbrugge, Serge; Warner, Roscoe L.; Sannomiya, Paulina; Piccolo, Nelson S.; Piccolo, Monica S.; Hugli, Tony E.; Ward, Peter A.; Till, Gerd O.; (1999). "Role of Chemotactic Factors in Neutrophil Activation After Thermal Injury in Rats." Inflammation 23(4): 371-385. <http://hdl.handle.net/2027.42/44526>en_US
dc.identifier.issn0360-3997en_US
dc.identifier.issn1573-2576en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44526
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10443799&dopt=citationen_US
dc.description.abstractAcute thermal trauma is well known to produce evidence of a “systemic inflammatory response” in vivo, as manifested by evidence of complement activation, appearance in plasma of a variety of inflammatory factors, and development of multi-organ injury. The current studies were focused on acute thermal injury of rat skin and factors responsible for accompanying activation of blood neutrophils. Acute thermal injury of rat skin resulted in a time-dependent loss of L-selectin and up-regulation of Mac-1 (CD11b/CD18) on blood neutrophils, with no changes in LFA-1 (CD11a/CD18). The loss of L-selectin was prevented by blockade of C5a but not by blockade of the α-chemokine, macrophage inflammatory protein-2 (MIP-2). C5a, the α chemokines, MIP-2 and keratinocyte-derived cytokine (KC), and platelet activating factor (PAF) contributed to up-regulation of blood neutrophil Mac-1. Blocking interventions against these mediators also blunted the degree of neutropenia developing after thermal trauma. These data suggest that activation of blood neutrophils after thermal trauma is related to the role of several chemotactic mediators. These studies may provide clues regarding factors responsible for development of the “systemic inflammatory response syndrome” after thermal injury in the experimental model employed.en_US
dc.format.extent794878 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherRheumatologyen_US
dc.subject.otherInternal Medicineen_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherPathologyen_US
dc.titleRole of Chemotactic Factors in Neutrophil Activation After Thermal Injury in Ratsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPathologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109; Pronto Socorro para Queimaduras, Goiania-GO, Brazilen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationotherPronto Socorro para Queimaduras, Goiania-GO, Brazilen_US
dc.contributor.affiliationotherDepartment of Experimental Anesthesiology, Erasmus University of Rotterdam, Rotterdam, The Netherlandsen_US
dc.contributor.affiliationotherDivision of Immunology, Scripps Research Institute, La Jolla, California, 92037en_US
dc.contributor.affiliationotherDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazilen_US
dc.contributor.affiliationotherPronto Socorro para Queimaduras, Goiania-GO, Brazilen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid10443799en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44526/1/10753_2004_Article_408821.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1020213717336en_US
dc.identifier.sourceInflammationen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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