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Human neutrophil phosphodiesterase

dc.contributor.authorSmolen, James E.en_US
dc.contributor.authorGeosits, Stephen J.en_US
dc.date.accessioned2006-09-11T14:56:46Z
dc.date.available2006-09-11T14:56:46Z
dc.date.issued1984-06en_US
dc.identifier.citationSmolen, James E.; Geosits, Stephen J.; (1984). "Human neutrophil phosphodiesterase." Inflammation 8(2): 193-199. <http://hdl.handle.net/2027.42/44535>en_US
dc.identifier.issn0360-3997en_US
dc.identifier.issn1573-2576en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44535
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6086523&dopt=citationen_US
dc.description.abstractExtracts of human neutrophils were examined for phosphodiesterase activity using a radiochemical assay. As reported by other investigators, both high- and low- K m forms of the enzyme were found. Although calmodulin could be measured in these extracts, human neutrophil phosphodiesterase proved not to be calmodulin dependent. Activity of the neutrophil phosphodiesterase was also not altered by physiologic concentrations of indomethacin, p -bromophenacyl bromide, eicosatetraenoic acid, or eicosatetraynoic acid, all inhibitors of arachidonic acid metabolism. These results are relevant to stimulus-secretion coupling in neutrophils, wherein calmodulin-dependent reactions play a vital role.en_US
dc.format.extent297147 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherInternal Medicineen_US
dc.subject.otherRheumatologyen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherPathologyen_US
dc.titleHuman neutrophil phosphodiesteraseen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPathologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Rhematology, Department of Medicine, New York University School of Medicine, 10016, New York, New York; Division of Pediatric Hematology/Oncology, F6515 Mott Children's Hospital, University of Michigan Medical School, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherDivision of Rhematology, Department of Medicine, New York University School of Medicine, 10016, New York, New Yorken_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid6086523en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44535/1/10753_2004_Article_BF00916094.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00916094en_US
dc.identifier.sourceInflammationen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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