Mediation and Modification of the Association Between Hopelessness, Hostility, and Progression of Carotid Atherosclerosis
dc.contributor.author | Kaplan, George A. | en_US |
dc.contributor.author | Pollitt, Ricardo A. | en_US |
dc.contributor.author | Daniel, Mark | en_US |
dc.contributor.author | Kaufman, Jay S. | en_US |
dc.contributor.author | Lynch, John W. | en_US |
dc.contributor.author | Salonen, Jukka T. | en_US |
dc.date.accessioned | 2006-09-11T15:18:50Z | |
dc.date.available | 2006-09-11T15:18:50Z | |
dc.date.issued | 2005-02 | en_US |
dc.identifier.citation | Pollitt, Ricardo A.; Daniel, Mark; Kaufman, Jay S.; Lynch, John W.; Salonen, Jukka T.; Kaplan, George A.; (2005). "Mediation and Modification of the Association Between Hopelessness, Hostility, and Progression of Carotid Atherosclerosis." Journal of Behavioral Medicine 28(1): 53-64. <http://hdl.handle.net/2027.42/44818> | en_US |
dc.identifier.issn | 1573-3521 | en_US |
dc.identifier.issn | 0160-7715 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44818 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15887876&dopt=citation | en_US |
dc.description.abstract | Hopelessness and hostility are linked to progression of carotid atherosclerosis (PCA). The purpose of this study was to replicate such relations and to evaluate the role of biological pathways involving hyperactivation of the sympathetic nervous system (SNS) and the hypothalamic–pituitary–adrenocortical (HPA) axis. PCA was evaluated by 4-year change in three ultrasound measures of intima-media thickness (IMT) in 1027 men aged 42–60 years at baseline. Effect modification and mediation of relationships between psychosocial factors and PCA were examined for the measures systolic blood pressure (SBP), fibrinogen, and waist-to-hip ratio (WHR), levels of which are indicative of activity along these pathways. Hopelessness and hostility were associated with PCA. Fibrinogen mediated to a moderate extent the association between hopelessness and PCA. SBP significantly modified the relation between hostility and PCA in participants of moderate hostility. The above biological pathways are implicated in the mechanisms connecting hopelessness, hostility, and PCA. | en_US |
dc.format.extent | 133092 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Springer Science + Business Media, Inc. | en_US |
dc.subject.other | Public Health/Gesundheitswesen | en_US |
dc.subject.other | Hostility | en_US |
dc.subject.other | SBP | en_US |
dc.subject.other | Psychology | en_US |
dc.subject.other | Clinical Psychology | en_US |
dc.subject.other | Health Psychology | en_US |
dc.subject.other | Hopelessness | en_US |
dc.subject.other | IMT | en_US |
dc.subject.other | Fibrinogen | en_US |
dc.title | Mediation and Modification of the Association Between Hopelessness, Hostility, and Progression of Carotid Atherosclerosis | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, Center for Social Epidemiology and Population Health, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Epidemiology, Center for Social Epidemiology and Population Health, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Département de Médecine Sociale et Preventive, l’ Université de Montréal, Montreal, Quebec | en_US |
dc.contributor.affiliationother | Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina | en_US |
dc.contributor.affiliationother | Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Epidemiology, School of Public Health, The University of North Carolina, Campus Box # 7435, Chapel Hill, North Carolina, 27599-7435 | en_US |
dc.contributor.affiliationother | Research Institute of Public Health and Department of Public Health and General Practice, The University of Kuopio, Kuopio, Finland; Inner Savo Health Centre, Suonenjoki, Finland | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15887876 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44818/1/10865_2005_Article_2563.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s10865-005-2563-y | en_US |
dc.identifier.source | Journal of Behavioral Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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