Immunoregulatory dysfunctions in type I diabetes: Natural and antibody-dependent cellular cytotoxic activities
dc.contributor.author | Nair, Madhavan P. N. | en_US |
dc.contributor.author | Lewis, Eric W. | en_US |
dc.contributor.author | Schwartz, Stanley A. | en_US |
dc.date.accessioned | 2006-09-11T15:21:19Z | |
dc.date.available | 2006-09-11T15:21:19Z | |
dc.date.issued | 1986-09 | en_US |
dc.identifier.citation | Nair, Madhavan P. N.; Lewis, Eric W.; Schwartz, Stanley A.; (1986). "Immunoregulatory dysfunctions in type I diabetes: Natural and antibody-dependent cellular cytotoxic activities." Journal of Clinical Immunology 6(5): 363-372. <http://hdl.handle.net/2027.42/44848> | en_US |
dc.identifier.issn | 1573-2592 | en_US |
dc.identifier.issn | 0271-9142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44848 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2429979&dopt=citation | en_US |
dc.description.abstract | Peripheral blood lymphocytes from 13 patients with established insulin-dependent diabetes mellitus (IDDM) and 2 prediabetic patients were examined for natural killer (NK) and antibody-dependent cellular cytotoxic activities (ADCC), lectin-dependent cellular cytotoxicity (LDCC), interferon- and interleukin-2-induced cytotoxicity, and concanavalin A-induced suppressor-cell activities in comparison with age-matched normal controls. IDDM patients demonstrated normal levels of NK and ADCC activities against K562 and antibody-coated SB target cells, respectively, compared to controls. IDDM patients showed normal levels of LDCC activity. Notable deviations from control values were, however, observed with diabetic lymphocytes in the following systems. Interferon-and interleukin-2-induced NK activities were significantly higher with IDDM lymphocytes than with control cells. IDDM lymphocytes precultured with concanavalin A demonstrated lower NK and ADCC activities than control cells and manifested decreased suppressor effects on the NK activity of normal allogeneic lymphocytes. Lymphocytes from one of two prediabetic patients showed increased NK, ADCC, and LDCC activities in comparison to controls. The increased interferon- and interleukin-2-induced enhancement of NK activity and reduced suppressor activity of lymphocytes from IDDM patients may be involved in the pathogenesis of the disease. | en_US |
dc.format.extent | 1234853 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Internal Medicine | en_US |
dc.subject.other | Interferon | en_US |
dc.subject.other | Immunoregulation | en_US |
dc.subject.other | Insulin-dependent Diabetes Mellitus | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Immunology | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.subject.other | Infectious Diseases | en_US |
dc.subject.other | Prediabetes | en_US |
dc.subject.other | Natural Killer Cells | en_US |
dc.subject.other | Interleukin-2 | en_US |
dc.title | Immunoregulatory dysfunctions in type I diabetes: Natural and antibody-dependent cellular cytotoxic activities | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, The University of Michigan, 48109, Ann Arbor, Michigan; Department of Epidemiology, The University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, The University of Michigan, 48109, Ann Arbor, Michigan; Department of Epidemiology, The University of Michigan, 48109, Ann Arbor, Michigan; The University of Michigan, 109 South Observatory, Room 1029 SPH-I, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, The University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2429979 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44848/1/10875_2004_Article_BF00915375.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00915375 | en_US |
dc.identifier.source | Journal of Clinical Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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