Histamine receptor activation by unsaturated (allyl and propargyl) homologs of histamine
dc.contributor.author | Banning, Jon W. | en_US |
dc.contributor.author | Griffith, Robert K. | en_US |
dc.contributor.author | Dipietro, Richard A. | en_US |
dc.date.accessioned | 2006-09-11T15:23:43Z | |
dc.date.available | 2006-09-11T15:23:43Z | |
dc.date.issued | 1985-12 | en_US |
dc.identifier.citation | Banning, Jon W.; Griffith, Robert K.; Dipietro, Richard A.; (1985). "Histamine receptor activation by unsaturated (allyl and propargyl) homologs of histamine." Agents and Actions 17(2): 138-144. <http://hdl.handle.net/2027.42/44880> | en_US |
dc.identifier.issn | 0065-4299 | en_US |
dc.identifier.issn | 1420-908X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44880 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4096303&dopt=citation | en_US |
dc.description.abstract | The spectrum of agonist activity for three new homologs of histamine (cis- and trans-imidazolylallylamine and imidazolylpropargylamine) was evaluated in the isolated guinea pig ileum and right atrium. The homologs were about three log units less potent than histamine in stimulating contractions of the longitudinal muscles of the ileum, but they were histamine-like, pharmacologically, because they were sensitive to blockade by pyrilamine and resistant to blockade by atropine. In the right atrium, these weak agonists were partially sensitive to blockade by cimetidine. The agonist activity of the cis-isomer in particular was completely blocked by a combination of cimetidine and propranolol, but resistant to reserpine treatment (neuronal catecholamine depletion). Therefore, these homologs of histamine have the ability to stimulate H 1 - and H 2 -histamine receptors and beta -adrenoreceptors in vitro . | en_US |
dc.format.extent | 578803 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Birkhäuser-Verlag; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Immunology | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Allergology | en_US |
dc.subject.other | Dermatology | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | Histamine receptor activation by unsaturated (allyl and propargyl) homologs of histamine | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicinal Chemistry, College of Pharmacy, The University of Michigan, 48109, Ann Arbor, MI; Agricultural Research Department, Chevron Chemical Co., 94804, Richmond, CA | en_US |
dc.contributor.affiliationum | Department of Medicinal Chemistry, College of Pharmacy, The University of Michigan, 48109, Ann Arbor, MI; Syntex Corporation, 94304, Palo Alto, CA | en_US |
dc.contributor.affiliationother | Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Wayne State University, 48202, Detroit, MI | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 4096303 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44880/1/11_2005_Article_BF01966582.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01966582 | en_US |
dc.identifier.source | Agents and Actions | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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