Quantitaton of rate of gastrointestinal and buccal absorption of acidic and basic drugs based on extraction theory
dc.contributor.author | Wagner, John G. | en_US |
dc.contributor.author | Sedman, Allen J. | en_US |
dc.date.accessioned | 2006-09-11T15:34:55Z | |
dc.date.available | 2006-09-11T15:34:55Z | |
dc.date.issued | 1973-02 | en_US |
dc.identifier.citation | Wagner, John G.; Sedman, Allen J.; (1973). "Quantitaton of rate of gastrointestinal and buccal absorption of acidic and basic drugs based on extraction theory." Journal of Pharmacokinetics and Biopharmaceutics 1(1): 23-50. <http://hdl.handle.net/2027.42/45024> | en_US |
dc.identifier.issn | 0090-466X | en_US |
dc.identifier.issn | 1573-8744 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45024 | |
dc.description.abstract | Equations have been derived which quantitatively describe the rate of gastrointestinal and buccal absorption of acidic and basic drugs as a function of pH of aqueous lumenal contents and time. The equations have been used to fit observed data in the literature, and the estimated parameters are reported. An equation which describes the renal clearance of an acidic or basic drug as a function of urinary pH is also derived. In essence, the equations quantitate the pH-partition hypothesis and explain most, if not all, related observed data in the literature. The results suggest that the aqueous diffusion layer may not rate-limit absorption of monomeric drug molecules but that absorption is rate-limited by transfer of drug out of the membrane in vivo. | en_US |
dc.format.extent | 1476416 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Extraction Theory | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Veterinary Medicine | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Rate of Absorption | en_US |
dc.subject.other | Rate of Renal Reabsorption | en_US |
dc.subject.other | Partition Coefficient in Vivo | en_US |
dc.subject.other | PH of Lumenal Contents | en_US |
dc.title | Quantitaton of rate of gastrointestinal and buccal absorption of acidic and basic drugs based on extraction theory | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy and Pharmacy Service, University Hospital, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy and Pharmacy Service, University Hospital, The University of Michigan, Ann Arbor, Michigan; Room W3535, Pharmacy Laboratory, University Hospital, 48104, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45024/1/10928_2005_Article_BF01060026.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01060026 | en_US |
dc.identifier.source | Journal of Pharmacokinetics and Biopharmaceutics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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