In Vitro and In Vivo availability of some commercial prednisolone tablets
dc.contributor.author | Blair, Donald C. | en_US |
dc.contributor.author | Stoll, Roger G. | en_US |
dc.contributor.author | Sullivan, Timothy J. | en_US |
dc.contributor.author | Sakmar, Ermelinda | en_US |
dc.contributor.author | Wagner, John G. | en_US |
dc.date.accessioned | 2006-09-11T15:36:09Z | |
dc.date.available | 2006-09-11T15:36:09Z | |
dc.date.issued | 1974-02 | en_US |
dc.identifier.citation | Sullivan, Timothy J.; Stoll, Roger G.; Sakmar, Ermelinda; Blair, Donald C.; Wagner, John G.; (1974). " In Vitro and In Vivo availability of some commercial prednisolone tablets." Journal of Pharmacokinetics and Biopharmaceutics 2(1): 29-41. <http://hdl.handle.net/2027.42/45041> | en_US |
dc.identifier.issn | 0090-466X | en_US |
dc.identifier.issn | 1573-8744 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45041 | |
dc.description.abstract | The in vitro dissolution rates of prednisolone from five commercially available 5- mg prednisolone tablets were determined in distilled water. The dissolution studies were repeated on the fastest- and slowest-dissolving brands using 0.01% polysorbate 80 in 0.1 N HCl as the dissolution medium. A two-way crossover bioavailability study was performed in 12 human male adult volunteers comparing the fastest- and slowest-dissolving brands. The plasma samples were assayed for prednisolone by a radioimmunoassay method. Statistical analysis of the data for the two brands showed no significant differences between average plasma levels of prednisolone at any sampling time. The results suggest that on the average the in vivo rates of dissolution of the two brands were essentially the same, and in vitro dissolution in 0.01% polysorbate 80–0.1 N HCl medium was better correlated with these in vivo results than dissolution in water . | en_US |
dc.format.extent | 580332 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Prednisolone Availability | en_US |
dc.subject.other | Prednisolone Tablets | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Bioavailability | en_US |
dc.subject.other | In Vivo- in Vitro Bioavailability Correlations | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Veterinary Medicine | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Radioimmunoassay for Prednisolone | en_US |
dc.title | In Vitro and In Vivo availability of some commercial prednisolone tablets | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48104, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48104, Ann Arbor, Michigan; Bioavailability Unit, The Upjohn Company, Kalamazoo, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48104, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48104, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48104, Ann Arbor, Michigan; Upjohn Center for Clinical Pharmacology, The University of Michigan, 48104, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45041/1/10928_2005_Article_BF01062144.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01062144 | en_US |
dc.identifier.source | Journal of Pharmacokinetics and Biopharmaceutics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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