The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculature in vitro and in vivo
dc.contributor.author | Schumacher, William A. | en_US |
dc.contributor.author | Fantone, Joseph C. | en_US |
dc.contributor.author | Kunkel, S. E. | en_US |
dc.contributor.author | Webb, R. Clinton | en_US |
dc.contributor.author | Lucchesi, Benedict Robert | en_US |
dc.date.accessioned | 2006-09-11T15:37:14Z | |
dc.date.available | 2006-09-11T15:37:14Z | |
dc.date.issued | 1991-11 | en_US |
dc.identifier.citation | Schumacher, W. A.; Fantone, J. C.; Kunkel, S. E.; Webb, R. C.; Lucchesi, B. R.; (1991). "The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculature in vitro and in vivo ." Agents and Actions 34 (3-4): 345-349. <http://hdl.handle.net/2027.42/45056> | en_US |
dc.identifier.issn | 0065-4299 | en_US |
dc.identifier.issn | 1420-908X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45056 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1810146&dopt=citation | en_US |
dc.description.abstract | The effect of complement fragments on coronary blood flow in vivo and the contraction of coronary arteries in vitro was determined. In pentobarbital anesthetized dogs, intraarterial bolus injection of C3a and C5a, zymosan-activated serum and methylcholine in the coronary vascular bed caused transient and dose-dependent increases in coronary blood flow. Similar increases were obtained with 25 μg of C3a (104±13%, n =5) and 0.1 μg of methylcholine (102±4%, n =3). Smaller, increases in blood flow were elicited by 25 μg of C5a (41±18%, n =4) and 0.2 ml, of zymosan-activated serum (48±5%, n =4). None of these responses were associated, with significant changes in left ventricular contractile force measured with a strain gauge, arterial blood pressure, and heart rate. C3a dilated the coronary vascular bed in conscious dogs with an activity equal to or greater than that observed in anesthetized dogs. Isolated canine coronary arteries that were precontracted with serotonin relaxed in response to C3a, whether or not the endothelium was intact. Overall these data suggest that physiologically high doses of anaphylactic complement fragments vasodilate the canine coronary circulation. | en_US |
dc.format.extent | 450305 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Birkhäuser-Verlag; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Immunology | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Allergology | en_US |
dc.subject.other | Dermatology | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculature in vitro and in vivo | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA; Bristol-Meyers Squibb Pharmaceutical Research Institute, P.O. Box 4000, 08543-4000, Princeton, NJ, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 1810146 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45056/1/11_2005_Article_BF01988727.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01988727 | en_US |
dc.identifier.source | Agents and Actions | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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