Rapid equilibration of warfarin between rat tissue and plasma
dc.contributor.author | Wagner, John G. | en_US |
dc.contributor.author | Benya, Theodore J. | en_US |
dc.date.accessioned | 2006-09-11T15:37:35Z | |
dc.date.available | 2006-09-11T15:37:35Z | |
dc.date.issued | 1975-08 | en_US |
dc.identifier.citation | Benya, Theodore J.; Wagner, John G.; (1975). "Rapid equilibration of warfarin between rat tissue and plasma." Journal of Pharmacokinetics and Biopharmaceutics 3(4): 237-255. <http://hdl.handle.net/2027.42/45061> | en_US |
dc.identifier.issn | 0090-466X | en_US |
dc.identifier.issn | 1573-8744 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45061 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1185522&dopt=citation | en_US |
dc.description.abstract | Plasma and tissue concentrations of warfarin in the rat were measured as a function of time following a 10 mg/kg intravenous dose. The mathematical interpretation of the experimental results suggested that the data could be explained in terms of a two-compartment open model. Following equilibration, which occurred within a few minutes after injection, individual tissue levels and plasma levels of warfarin were found to be always directly proportional . | en_US |
dc.format.extent | 857753 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Tissue Binding | en_US |
dc.subject.other | Warfarin | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Tissue Distribution | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Veterinary Medicine | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Linear Pharmacokinetics | en_US |
dc.subject.other | Plasma Protein Binding | en_US |
dc.title | Rapid equilibration of warfarin between rat tissue and plasma | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, University of Michigan, 48104, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | College of Pharmacy, Ohio Northern University, 45810, Ada, Ohio | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 1185522 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45061/1/10928_2005_Article_BF01066920.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01066920 | en_US |
dc.identifier.source | Journal of Pharmacokinetics and Biopharmaceutics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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