A Population Pharmacokinetic Analysis of Milrinone in Pediatric Patients After Cardiac Surgery
dc.contributor.author | Chang, Anthony C. | en_US |
dc.contributor.author | Nelson, David P. | en_US |
dc.contributor.author | Atz, Andrew M. | en_US |
dc.contributor.author | Hoffman, Timothy M. | en_US |
dc.contributor.author | Bailey, James M. | en_US |
dc.contributor.author | Wessel, David L. | en_US |
dc.contributor.author | Kulik, Thomas J. | en_US |
dc.contributor.author | Spray, Thomas L. | en_US |
dc.contributor.author | Akbary, Akbar | en_US |
dc.contributor.author | Miller, Richard P. | en_US |
dc.contributor.author | Wernovsky, Gil | en_US |
dc.date.accessioned | 2006-09-11T15:37:44Z | |
dc.date.available | 2006-09-11T15:37:44Z | |
dc.date.issued | 2004-02 | en_US |
dc.identifier.citation | Bailey, James M.; Hoffman, Timothy M.; Wessel, David L.; Nelson, David P.; Atz, Andrew M.; Chang, Anthony C.; Kulik, Thomas J.; Spray, Thomas L.; Akbary, Akbar; Miller, Richard P.; Wernovsky, Gil; (2004). "A Population Pharmacokinetic Analysis of Milrinone in Pediatric Patients After Cardiac Surgery." Journal of Pharmacokinetics and Pharmacodynamics 31(1): 43-59. <http://hdl.handle.net/2027.42/45063> | en_US |
dc.identifier.issn | 1567-567X | en_US |
dc.identifier.issn | 1573-8744 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45063 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15346851&dopt=citation | en_US |
dc.description.abstract | The purpose of this study was to ascertain the optimal pharmacokinetic model for milrinone in pediatric patients after cardiac surgery when milrinone was administered as a slow loading dose followed by a constant-rate infusion. The data used for pharmacokinetic analysis were collected in a prospective, randomized, placebo-controlled multi-center trial of milrinone as prophylaxis for the development of low cardiac output syndrome after surgery for repair of complex congenital cardiac defects. Two blood samples were randomly collected from each patient for determination of plasma milrinone concentrations with subsequent population pharmacokinetic modeling. The pharmacokinetics of milrinone in pediatric patients under 6year's age were best described by a weight-normalized one compartment model after a slow loading dose followed by a constant-rate infusion. The volume of distribution was 482mlkg −1 , and was independent of age. Clearance was a linear function of age given by Cl=2.42mlkg −1 min −1 [1+0.0396*age]. | en_US |
dc.format.extent | 190053 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Mixed-effects Modeling | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Congenital Heart Disease | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Veterinary Medicine | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Phosphodiesterase Inhibitors | en_US |
dc.subject.other | Milrinone | en_US |
dc.subject.other | Pharmacokinetics | en_US |
dc.title | A Population Pharmacokinetic Analysis of Milrinone in Pediatric Patients After Cardiac Surgery | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Hospital, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | The Children's Hospital of Philadelphia, Philadelphia, PA | en_US |
dc.contributor.affiliationother | Sanofi-Synthelabo Inc., NewYork, NY | en_US |
dc.contributor.affiliationother | Emory University School of Medicine, Atlanta, GA; Department of Anesthesiology, Northeast Georgia Medical Center, Anesthesia Associates of Gainesville, 200 S. Enota Drive, Gainesville, Georgia, 30501 | en_US |
dc.contributor.affiliationother | Columbus Children's Hospital, Columbus, OH | en_US |
dc.contributor.affiliationother | Boston Children's Hospital, Boston, MA | en_US |
dc.contributor.affiliationother | Cincinnati, OH | en_US |
dc.contributor.affiliationother | Medical University of South Carolina, Charleston, SC | en_US |
dc.contributor.affiliationother | Texas Children's Hospital, Houston, TX | en_US |
dc.contributor.affiliationother | The Children's Hospital of Philadelphia, Philadelphia, PA | en_US |
dc.contributor.affiliationother | Sanofi-Synthelabo Inc., NewYork, NY | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15346851 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45063/1/10928_2004_Article_485925.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/B:JOPA.0000029488.45177.48 | en_US |
dc.identifier.source | Journal of Pharmacokinetics and Pharmacodynamics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.